2. PROTAC Apoptosis Autophagy
  3. Ligands for E3 Ligase Autophagy Apoptosis
  4. Thalidomide-5,6-F

Thalidomide-5,6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-F can be connected to the ligand for protein by a linker to form PROTACs.

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Thalidomide-5,6-F Chemical Structure

Thalidomide-5,6-F Chemical Structure

CAS No. : 1496997-41-1

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Based on 1 publication(s) in Google Scholar

Thalidomide-5,6-F Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP

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Description

Thalidomide-5,6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-F can be connected to the ligand for protein by a linker to form PROTACs[1].

IC50 & Target[1]

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thalidomide-5,6-F Related Antibodies
Molecular Weight

294.21

Formula

C13H8F2N2O4
CAS No.
Appearance

Solid

Color

Off-white to gray

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=C(F)C(F)=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (113.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3989 mL 16.9947 mL 33.9893 mL
5 mM 0.6798 mL 3.3989 mL 6.7979 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.84%

COA (250 KB) HNMR (243 KB) LCMS (105 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3989 mL 16.9947 mL 33.9893 mL 84.9733 mL
5 mM 0.6798 mL 3.3989 mL 6.7979 mL 16.9947 mL
10 mM 0.3399 mL 1.6995 mL 3.3989 mL 8.4973 mL
15 mM 0.2266 mL 1.1330 mL 2.2660 mL 5.6649 mL
20 mM 0.1699 mL 0.8497 mL 1.6995 mL 4.2487 mL
25 mM 0.1360 mL 0.6798 mL 1.3596 mL 3.3989 mL
30 mM 0.1133 mL 0.5665 mL 1.1330 mL 2.8324 mL
40 mM 0.0850 mL 0.4249 mL 0.8497 mL 2.1243 mL
50 mM 0.0680 mL 0.3399 mL 0.6798 mL 1.6995 mL
60 mM 0.0566 mL 0.2832 mL 0.5665 mL 1.4162 mL
80 mM 0.0425 mL 0.2124 mL 0.4249 mL 1.0622 mL
100 mM 0.0340 mL 0.1699 mL 0.3399 mL 0.8497 mL
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Thalidomide-5,6-F Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-5,6-F1496997-41-1Ligands for E3 LigaseAutophagyApoptosisE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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