2. PROTAC Immunology/Inflammation
  3. PROTACs IRAK
  4. PROTAC IRAK4 degrader-10

PROTAC IRAK4 degrader-10 (compound 10) is an oral active PROTAC based on Cereblon ligand, and induces the degradation of IRAK4 with maximum degradation of 95.94% and the DC50 of 7.68 nM in HEK293 cells (Sturcture Note:(Blue: Cereblon ligand, Black: linker；Pink: IRAK4 ligand).

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PROTAC IRAK4 degrader-10 Chemical Structure

PROTAC IRAK4 degrader-10 Chemical Structure

CAS No. : 3033829-95-4

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PROTAC IRAK4 degrader-10 Related Antibodies

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IRAK1 IRAK4

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Description

PROTAC IRAK4 degrader-10 (compound 10) is an oral active PROTAC based on Cereblon ligand, and induces the degradation of IRAK4 with maximum degradation of 95.94% and the DC50 of 7.68 nM in HEK293 cells (Sturcture Note:(Blue: Cereblon ligand, Black: linker；Pink: IRAK4 ligand)[1].

Molecular Weight

826.86

Formula

C43H45F3N8O6
CAS No.
SMILES

O=C(C1=NC(C2C(F)(F)C2)=CC=C1)NC3=CN4C(C(F)=C3C(C)(O)C)=NC(C5CCN(CC6CCN(C7=CC8=C(C(N(C(CC9)C(NC9=O)=O)C8=O)=O)C=C7)CC6)CC5)=C4
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC IRAK4 degrader-10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC IRAK4 degrader-103033829-95-4PROTACsIRAKInterleukin-1 receptor associated kinaseIL-1R associated kinaseHEK293Inhibitorinhibitorinhibit

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