2. PROTAC Immunology/Inflammation
  3. PROTACs IRAK
  4. PROTAC IRAK4 degrader-12

PROTAC IRAK4 degrader-12 is a PROTAC based on Cereblon ligand, inducing a maximum degradation rate of IRAK4 of 108.46% in K562 cells with an IC50 value of 4.87 nM ( Structure Note: Pink, IRAK4 inhibitor (HY-168611); Blue, E3 (HY-W733885); Black, linker (HY-168613)).

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PROTAC IRAK4 degrader-12 Chemical Structure

PROTAC IRAK4 degrader-12 Chemical Structure

CAS No. : 2919995-09-6

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PROTAC IRAK4 degrader-12 Related Antibodies

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IRAK1 IRAK4

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Description

PROTAC IRAK4 degrader-12 is a PROTAC based on Cereblon ligand, inducing a maximum degradation rate of IRAK4 of 108.46% in K562 cells with an IC50 value of 4.87 nM ( Structure Note: Pink, IRAK4 inhibitor (HY-168611); Blue, E3 (HY-W733885); Black, linker (HY-168613))[1].

Molecular Weight

926.41

Formula

C46H50ClF2N11O6
CAS No.
SMILES

O=C1CCC(C(N1)=O)C2=NOC3=C2C4=C(C(NC(CN5CCN(CC5)C[C@@H]6CC[C@H](CC6)N7C=C(C(C(F)F)=N7)NC(C8=COC(C9=CC(NCC%10CC%10)=NC=C9)=N8)=O)=O)=CC=C4)C=C3.Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC IRAK4 degrader-12 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC IRAK4 degrader-122919995-09-6PROTACsIRAKInterleukin-1 receptor associated kinaseIL-1R associated kinaseIRAK4DegraderK562Inhibitorinhibitorinhibit

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PROTAC IRAK4 degrader-12
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