2. Immunology/Inflammation PROTAC
  3. PROTACs IRAK
  4. PROTAC IRAK4 degrader-8

PROTAC IRAK4 degrader-8 (Compound 2) is a PROTAC IRAK4 degrader (IC50: 15.5 nM). PROTAC IRAK4 degrader-8 degrades IRAK4 in THP-1 cells (DC50: 1.8 nM)。PROTAC IRAK4 degrader-8 also inhibits L-6 production in human whole blood and LPS-induced human PBMC cells, with IC50s of 246 nM and 2.2 nM respectively.

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PROTAC IRAK4 degrader-8 Chemical Structure

PROTAC IRAK4 degrader-8 Chemical Structure

CAS No. : 2911615-06-8

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PROTAC IRAK4 degrader-8 Related Antibodies

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IRAK1 IRAK4

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Description

PROTAC IRAK4 degrader-8 (Compound 2) is a PROTAC IRAK4 degrader (IC50: 15.5 nM). PROTAC IRAK4 degrader-8 degrades IRAK4 in THP-1 cells (DC50: 1.8 nM)。PROTAC IRAK4 degrader-8 also inhibits L-6 production in human whole blood and LPS-induced human PBMC cells, with IC50s of 246 nM and 2.2 nM respectively[1].

Molecular Weight

874.38

Formula

C43H50ClF2N11O5
CAS No.
SMILES

O=C(C(C=C1)=CC(N(CCC2=O)C(N2)=O)=C1Cl)N3CCC(CCN4C[C@H]5CC[C@H](N(N=C6C(F)F)C=C6NC(C7=C(N=C(N8[C@](CO9)([H])C[C@]9([H])C8)C=C%10)N%10N=C7)=O)CC5)(CC4)CC3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC IRAK4 degrader-8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC IRAK4 degrader-82911615-06-8PROTACsIRAKInterleukin-1 receptor associated kinaseIL-1R associated kinasePROTACL-6PBMChuman whole bloodTHP-1 cellIRAK4 degraderInhibitorinhibitorinhibit

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PROTAC IRAK4 degrader-8
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