2. GPCR/G Protein PROTAC MAPK/ERK Pathway
  3. PROTACs Ras
  4. PROTAC KRAS G12C degrader-2

PROTAC KRAS G12C degrader-2 (compound 432) is a modulator of K-Ras protein hydrolysis. PROTAC KRAS G12C degrader-2 is a bifunctional compound, which contain on one end a cereblon inhibitor of apoptosis proteins (IAP) and on the other end a moiety which binds KRAS.

For research use only. We do not sell to patients.

PROTAC KRAS G12C degrader-2 Chemical Structure

PROTAC KRAS G12C degrader-2 Chemical Structure

CAS No. : 2378257-72-6

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1 mg USD 548 In-stock
5 mg USD 1370 In-stock
10 mg USD 2325 In-stock
25 mg USD 4300 In-stock
50 mg USD 6450 In-stock
100 mg USD 9675 In-stock
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Based on 1 publication(s) in Google Scholar

PROTAC KRAS G12C degrader-2 Related Antibodies

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Description

PROTAC KRAS G12C degrader-2 (compound 432) is a modulator of K-Ras protein hydrolysis. PROTAC KRAS G12C degrader-2 is a bifunctional compound, which contain on one end a cereblon inhibitor of apoptosis proteins (IAP) and on the other end a moiety which binds KRAS[1].

Molecular Weight

958.47

Formula

C51H53ClFN9O7
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

FC1=C(C2=CC(O)=CC3=C2C=CC=C3)C(Cl)=CC4=C1N=C(O[C@H](C)CN5CCN(CC5)CC6CCN(C7=CC=C(C(N(C8C(NC(CC8)=O)=O)C9=O)=O)C9=C7)CC6)N=C4N%10CCN(CC%10)C(C=C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (52.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0433 mL 5.2166 mL 10.4333 mL
5 mM 0.2087 mL 1.0433 mL 2.0867 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0433 mL 5.2166 mL 10.4333 mL 26.0832 mL
5 mM 0.2087 mL 1.0433 mL 2.0867 mL 5.2166 mL
10 mM 0.1043 mL 0.5217 mL 1.0433 mL 2.6083 mL
15 mM 0.0696 mL 0.3478 mL 0.6956 mL 1.7389 mL
20 mM 0.0522 mL 0.2608 mL 0.5217 mL 1.3042 mL
25 mM 0.0417 mL 0.2087 mL 0.4173 mL 1.0433 mL
30 mM 0.0348 mL 0.1739 mL 0.3478 mL 0.8694 mL
40 mM 0.0261 mL 0.1304 mL 0.2608 mL 0.6521 mL
50 mM 0.0209 mL 0.1043 mL 0.2087 mL 0.5217 mL
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PROTAC KRAS G12C degrader-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC KRAS G12C degrader-22378257-72-6PROTACsRasprotein hydrolysisKRASmodulatorPROTACInhibitorinhibitorinhibit

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