PROTAC KRAS G12C degrader-2

Cat. No.: HY-153821 Purity: 98.45%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

PROTAC KRAS G12C degrader-2 (compound 432) is a modulator of K-Ras protein hydrolysis. PROTAC KRAS G12C degrader-2 is a bifunctional compound, which contain on one end a cereblon inhibitor of apoptosis proteins (IAP) and on the other end a moiety which binds KRAS.

For research use only. We do not sell to patients.

PROTAC KRAS G12C degrader-2 Chemical Structure

CAS No. : 2378257-72-6

Size	Price	Stock	Quantity
1 mg	USD 548	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1370	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 2325	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 4300	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 6450	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 9675	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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K-Ras H-Ras N-Ras Ras

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

958.47

Formula

C₅₁H₅₃ClFN₉O₇

CAS No.

2378257-72-6

Appearance

Solid

Color

Light yellow to yellow

SMILES

FC1=C(C2=CC(O)=CC3=C2C=CC=C3)C(Cl)=CC4=C1N=C(O[C@H](C)CN5CCN(CC5)CC6CCN(C7=CC=C(C(N(C8C(NC(CC8)=O)=O)C9=O)=O)C9=C7)CC6)N=C4N%10CCN(CC%10)C(C=C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (52.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0433 mL	5.2166 mL	10.4333 mL
5 mM	0.2087 mL	1.0433 mL	2.0867 mL
10 mM	0.1043 mL	0.5217 mL	1.0433 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.45%

Select Batch:

Data Sheet (266 KB) SDS (252 KB)

COA (246 KB) HNMR (289 KB) RP-HPLC (268 KB) LCMS (99 KB)

Handling Instructions (2659 KB)

References

[1]. Crew Andrew, et al. Preparation of bifunctional compounds as modulators of proteolysis useful for treating cancer. World Intellectual Property Organization, WO2019195609 A2. 2019-10-10.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0433 mL	5.2166 mL	10.4333 mL	26.0832 mL
	5 mM	0.2087 mL	1.0433 mL	2.0867 mL	5.2166 mL
	10 mM	0.1043 mL	0.5217 mL	1.0433 mL	2.6083 mL
	15 mM	0.0696 mL	0.3478 mL	0.6956 mL	1.7389 mL
	20 mM	0.0522 mL	0.2608 mL	0.5217 mL	1.3042 mL
	25 mM	0.0417 mL	0.2087 mL	0.4173 mL	1.0433 mL
	30 mM	0.0348 mL	0.1739 mL	0.3478 mL	0.8694 mL
	40 mM	0.0261 mL	0.1304 mL	0.2608 mL	0.6521 mL
	50 mM	0.0209 mL	0.1043 mL	0.2087 mL	0.5217 mL