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  4. PROTAC KRAS G12D degrader 1

PROTAC KRAS G12D degrader 1 is a potent, rapid, and selective degrader of protac KRASG12D with DC50 of 38.06 nM. PROTAC KRAS G12D degrader 1 showes significant antitumor efficacy.

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PROTAC KRAS G12D degrader 1 Chemical Structure

PROTAC KRAS G12D degrader 1 Chemical Structure

CAS No. : 3033583-54-6

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1 mg USD 470 In-stock
5 mg USD 1040 In-stock
10 mg USD 1666 In-stock
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Based on 1 publication(s) in Google Scholar

PROTAC KRAS G12D degrader 1 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC KRAS G12D degrader 1 is a potent, rapid, and selective degrader of protac KRASG12D with DC50 of 38.06 nM. PROTAC KRAS G12D degrader 1 showes significant antitumor efficacy[1].

Molecular Weight

1103.33

Formula

C59H72F2N10O7S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

FC1=C(CC)C2=C(C3=NC=C4C(N=C(OC[C@@H]5CCCN5CCCCOCC(N[C@@H](C(C)(C)C)C(N6[C@H](C(N[C@@H](C)C7=CC=C(C8=C(C)N=CS8)C=C7)=O)C[C@@H](O)C6)=O)=O)N=C4N9C[C@H]%10N[C@H](CC%10)C9)=C3F)C=C(O)C=C2C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (9.06 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9063 mL 4.5317 mL 9.0635 mL
5 mM 0.1813 mL 0.9063 mL 1.8127 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9063 mL 4.5317 mL 9.0635 mL 22.6587 mL
5 mM 0.1813 mL 0.9063 mL 1.8127 mL 4.5317 mL
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PROTAC KRAS G12D degrader 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC KRAS G12D degrader 13033583-54-6PROTACsPROTACAsPC-1HPAF-IIPANCInhibitorinhibitorinhibit

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