2. PROTAC
  3. PROTAC Linkers
  4. Boc-NH-PEG3

Boc-NH-PEG3  (Synonyms: PROTAC Linker 10)

Cat. No.: HY-W017772 Purity: ≥98.0%
COA Handling Instructions

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Boc-NH-PEG3 (PROTAC Linker 10) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Boc-NH-PEG3 Chemical Structure

Boc-NH-PEG3 Chemical Structure

CAS No. : 139115-92-7

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500 mg USD 95 In-stock
1 g USD 130 In-stock
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Based on 1 publication(s) in Google Scholar

Boc-NH-PEG3 Related Antibodies

Top Publications Citing Use of Products

View All PROTAC Linkers Isoform Specific Products:

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

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Description

Boc-NH-PEG3 (PROTAC Linker 10) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Boc-NH-PEG3 Related Antibodies
Molecular Weight

249.30

Formula

C11H23NO5
CAS No.
Appearance

Liquid (Density: 1.071±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(OC(C)(C)C)NCCOCCOCCO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (401.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0112 mL 20.0562 mL 40.1123 mL
5 mM 0.8022 mL 4.0112 mL 8.0225 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (241 KB) HNMR (229 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0112 mL 20.0562 mL 40.1123 mL 100.2808 mL
5 mM 0.8022 mL 4.0112 mL 8.0225 mL 20.0562 mL
10 mM 0.4011 mL 2.0056 mL 4.0112 mL 10.0281 mL
15 mM 0.2674 mL 1.3371 mL 2.6742 mL 6.6854 mL
20 mM 0.2006 mL 1.0028 mL 2.0056 mL 5.0140 mL
25 mM 0.1604 mL 0.8022 mL 1.6045 mL 4.0112 mL
30 mM 0.1337 mL 0.6685 mL 1.3371 mL 3.3427 mL
40 mM 0.1003 mL 0.5014 mL 1.0028 mL 2.5070 mL
50 mM 0.0802 mL 0.4011 mL 0.8022 mL 2.0056 mL
60 mM 0.0669 mL 0.3343 mL 0.6685 mL 1.6713 mL
80 mM 0.0501 mL 0.2507 mL 0.5014 mL 1.2535 mL
100 mM 0.0401 mL 0.2006 mL 0.4011 mL 1.0028 mL
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Boc-NH-PEG3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Boc-NH-PEG3139115-92-7PROTAC Linker 10PROTAC Linker10PROTAC Linker-10PROTAC LinkersInhibitorinhibitorinhibit

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