2. PROTAC
  3. PROTAC Linkers
  4. NH2-PEG3-C2-NH-Boc

NH2-PEG3-C2-NH-Boc  (Synonyms: PROTAC Linker 15)

Cat. No.: HY-42776 Purity: ≥98.0%
COA Handling Instructions

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NH2-PEG3-C2-NH-Boc (PROTAC Linker 15) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

NH2-PEG3-C2-NH-Boc Chemical Structure

NH2-PEG3-C2-NH-Boc Chemical Structure

CAS No. : 101187-40-0

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Based on 1 publication(s) in Google Scholar

NH2-PEG3-C2-NH-Boc Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE NH2-PEG3-C2-NH-Boc

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

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  • Purity & Documentation

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Description

NH2-PEG3-C2-NH-Boc (PROTAC Linker 15) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1][2].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
NH2-PEG3-C2-NH-Boc can serve as an intermediate for the synthesis of Iodide ACETYL-Tailed Linker: NH2-PEG3-C2-NH-Boc is dissolved in 30 mL of dichloromethane (DCM) and reacted with Iodoacetic acid N-hydroxysuccinimide (NHS) ester (linker I) (HY-W011541) (192 mg, 0.68 mmol) and 4-methylmorpholine (77 µL, 0.68 mmol) at room temperature for 1 hour. After silica gel column chromatography and solvent removal, a brown oily liquid (linker II) is obtained. Subsequently, linker II is mixed with 10 mL of DCM/TFA solution, and upon removal of the solvent, Iodide ACETYL-Tailed Linker is obtained without further purification[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NH2-PEG3-C2-NH-Boc Related Antibodies
Molecular Weight

292.37

Formula

C13H28N2O5
CAS No.
Appearance

Liquid (Density: 1.050±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

NCCOCCOCCOCCNC(OC(C)(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (342.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4203 mL 17.1016 mL 34.2032 mL
5 mM 0.6841 mL 3.4203 mL 6.8406 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.34%

COA (240 KB) HNMR (133 KB) LCMS (138 KB) GC (181 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4203 mL 17.1016 mL 34.2032 mL 85.5081 mL
5 mM 0.6841 mL 3.4203 mL 6.8406 mL 17.1016 mL
10 mM 0.3420 mL 1.7102 mL 3.4203 mL 8.5508 mL
15 mM 0.2280 mL 1.1401 mL 2.2802 mL 5.7005 mL
20 mM 0.1710 mL 0.8551 mL 1.7102 mL 4.2754 mL
25 mM 0.1368 mL 0.6841 mL 1.3681 mL 3.4203 mL
30 mM 0.1140 mL 0.5701 mL 1.1401 mL 2.8503 mL
40 mM 0.0855 mL 0.4275 mL 0.8551 mL 2.1377 mL
50 mM 0.0684 mL 0.3420 mL 0.6841 mL 1.7102 mL
60 mM 0.0570 mL 0.2850 mL 0.5701 mL 1.4251 mL
80 mM 0.0428 mL 0.2138 mL 0.4275 mL 1.0689 mL
100 mM 0.0342 mL 0.1710 mL 0.3420 mL 0.8551 mL
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NH2-PEG3-C2-NH-Boc Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NH2-PEG3-C2-NH-Boc101187-40-0PROTAC Linker 15PROTAC Linker15PROTAC Linker-15PROTAC LinkersInhibitorinhibitorinhibit

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