2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Apoptosis
  3. ROR Apoptosis
  4. PROTAC ROR1 degrader-1

PROTAC ROR1 degrader-1 (Compound 11d) is a PROTAC degrader for pseudokinase ROR1 that degrades ROR1 in NSCLC cells with a DC50s of 40-80 nM. PROTAC ROR1 degrader-1 causes the cleavage of PARP and induces apoptosis in NCI-H23. (Pink: ligand for target protein ROR1 ligand-1 (HY-170996); Black: linker (HY-W014787); Blue: ligand for VHL E3 ligase (S,R,S)-AHPC (HY-125845))

For research use only. We do not sell to patients.

PROTAC ROR1 degrader-1 Chemical Structure

PROTAC ROR1 degrader-1 Chemical Structure

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Description

PROTAC ROR1 degrader-1 (Compound 11d) is a PROTAC degrader for pseudokinase ROR1 that degrades ROR1 in NSCLC cells with a DC50s of 40-80 nM. PROTAC ROR1 degrader-1 causes the cleavage of PARP and induces apoptosis in NCI-H23[1]. (Pink: ligand for target protein ROR1 ligand-1 (HY-170996); Black: linker (HY-W014787); Blue: ligand for VHL E3 ligase (S,R,S)-AHPC (HY-125845))

Molecular Weight

1081.22

Formula

C55H74BrN11O5S
SMILES

O=C([C@H]1N(C([C@@H](NC(CCCCCCCCC(N2CCN(C3=CC=C(C4=NC5=C(NC6CCN(CC)CC6)C(Br)=CN=C5N4)C=C3)CC2)=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC7=CC=C(C8=C(C)N=CS8)C=C7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC ROR1 degrader-1 Related Classifications

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Keywords:

PROTAC ROR1 degrader-1RORApoptosisRAR-related orphan receptorNSCLCNCI-H23NCI-H1299NCI-H1975NCI-H460Inhibitorinhibitorinhibit

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PROTAC ROR1 degrader-1
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