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  4. PROTAC TBL1X degrader-1

PROTAC TBL1X degrader-1 (Compound TD11) is a PROTAC degrader for Transducin β-like protein 1 X-linked (TBL1X), and exhibits cytotoxicity in lymphoma cell Riva, Pfeiffer and Granta-519 with IC50 of 0.795, 0.397 and 0.522 μM, respectively. (Pink: ligand for target protein: TBL1X ligand 1 (HY-168191); Black: linker (HY-168193); Blue: ligand for E3 ligase: Thalidomide 4-fluoride (HY-41547))

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PROTAC TBL1X degrader-1 Chemical Structure

PROTAC TBL1X degrader-1 Chemical Structure

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PROTAC TBL1X degrader-1 Related Antibodies

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Description

PROTAC TBL1X degrader-1 (Compound TD11) is a PROTAC degrader for Transducin β-like protein 1 X-linked (TBL1X), and exhibits cytotoxicity in lymphoma cell Riva, Pfeiffer and Granta-519 with IC50 of 0.795, 0.397 and 0.522 μM, respectively. (Pink: ligand for target protein: TBL1X ligand 1 (HY-168191); Black: linker (HY-168193); Blue: ligand for E3 ligase: Thalidomide 4-fluoride (HY-41547))[1]

Molecular Weight

1001.18

Formula

C49H60N8O11S2
SMILES

O=S(C1=CC=C2C(/C(C(C=C(S(N3CC(C)CC(C)C3)(=O)=O)C=C4)=C4/C2=N\OCCCNC(CCCCNC5=C(C(N(C6C(NC(CC6)=O)=O)C7=O)=O)C7=CC=C5)=O)=N/O)=C1)(N8CC(C)CC(C)C8)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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PROTAC TBL1X degrader-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC TBL1X degrader-1PROTACsdiffuse large B-cell lymphomaDLBCLlymphomaRivaPfeifferGranta-519Inhibitorinhibitorinhibit

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