PROTAC VHL-type degrader-1

Cat. No.: HY-158345 Purity: 98.01%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

PROTAC VHL-type degrader-1 (compound 9b) is a VHL-type PROTAC degrader. PROTAC VHL-type degrader-1 induces ATM degradation synergistically enhancing the efficacy of ATR inhibitor AZD6738.

For research use only. We do not sell to patients.

PROTAC VHL-type degrader-1 Chemical Structure

CAS No. : 2821804-13-9

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

PROTAC VHL-type degrader-1 (compound 9b) is a VHL-type PROTAC degrader. PROTAC VHL-type degrader-1 induces ATM degradation synergistically enhancing the efficacy of ATR inhibitor AZD6738^[1].

Molecular Weight

898.08

Formula

C₄₉H₅₅N₉O₆S

CAS No.

2821804-13-9

Appearance

Solid

Color

Orange to reddish brown

SMILES

O=C([C@H]1N(C([C@@H](NC(CCCCCN2N=NC(CCCN3C(/C(C4=C3C=CC=C4)=C5C(NC6=C/5C=CC=C6)=O)=O)=C2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC7=CC=C(C8=C(C)N=CS8)C=C7

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (111.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1135 mL	5.5674 mL	11.1349 mL
5 mM	0.2227 mL	1.1135 mL	2.2270 mL
10 mM	0.1113 mL	0.5567 mL	1.1135 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.01%

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Data Sheet (271 KB) SDS (252 KB)

COA (251 KB) HNMR (193 KB) RP-HPLC (244 KB) MS (69 KB)

Handling Instructions (2659 KB)

References

[1]. Ting-Ting Liu, et al. Discovery of a Meisoindigo-Derived PROTAC as the ATM Degrader: Revolutionizing Colorectal Cancer Therapy via Synthetic Lethality with ATR Inhibitors. J. Med. Chem. 2024, 67, 9, 7620–7634.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1135 mL	5.5674 mL	11.1349 mL	27.8372 mL
	5 mM	0.2227 mL	1.1135 mL	2.2270 mL	5.5674 mL
	10 mM	0.1113 mL	0.5567 mL	1.1135 mL	2.7837 mL
	15 mM	0.0742 mL	0.3712 mL	0.7423 mL	1.8558 mL
	20 mM	0.0557 mL	0.2784 mL	0.5567 mL	1.3919 mL
	25 mM	0.0445 mL	0.2227 mL	0.4454 mL	1.1135 mL
	30 mM	0.0371 mL	0.1856 mL	0.3712 mL	0.9279 mL
	40 mM	0.0278 mL	0.1392 mL	0.2784 mL	0.6959 mL
	50 mM	0.0223 mL	0.1113 mL	0.2227 mL	0.5567 mL
	60 mM	0.0186 mL	0.0928 mL	0.1856 mL	0.4640 mL
	80 mM	0.0139 mL	0.0696 mL	0.1392 mL	0.3480 mL
	100 mM	0.0111 mL	0.0557 mL	0.1113 mL	0.2784 mL