2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. TGF-beta Superfamily
  5. Bone Morphogenetic Proteins (BMPs) Growth Differentiation Factor
  6. BMP-9/GDF-2

BMP-9/GDF-2

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BMP-9 is also known as growth differentiation factor-2 (GDF-2). BMP-9 belongs to TGFβ superfamily and signals through ALK1. BMP-9 is a vascular quiescence factor maintaining endothelial homeostasis[1]. BMP-9 binds to ALK1 with a very high affinity (Kd: 29 nM). BMP-9 is mainly produced by the liver, specifically by hepatocytes, and at a lower level by the lungs and the brain[2]. BMP-9 also induces bone formation. Specifically, the activation of ALK1 will eventually lead to phosphorylation and heterodimeric formation of Smad proteins. These Smads proteins can then interact with Smad4 for proper nuclear localization, which is necessary for proper BMP9-induced osteogenic differentiation[3]. Human BMP-9 shares about 80% aa sequence identity with mouse.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P700033AF
    Animal-Free BMP-9/GDF-2 Protein, Human (His)

    GDF-2; BMP-9; GDF2; BMP9

    		Human E. coli
    The BMP-9/GDF-2 protein is a potent inhibitor of angiogenesis that selectively signals through AVRL1 in endothelial cells. Its signaling pathway requires the TGF-β coreceptor endoglin/ENG to effectively activate SMAD1. Animal-Free BMP-9/GDF-2 Protein, Human (His) is the recombinant human-derived animal-FreeBMP-9/GDF-2 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free BMP-9/GDF-2 Protein, Human (His) is 110 a.a., with molecular weight of ~12.89 kDa.
  • HY-P700530
    GDF-2 Protein, Human (P. pastoris, His)

    GDF-2; BMP-9; GDF2; BMP9

    		Human P. pastoris
    The BMP-9/GDF-2 protein is a potent inhibitor of angiogenesis that selectively signals through AVRL1 in endothelial cells. Its signaling pathway requires the TGF-β coreceptor endoglin/ENG to effectively activate SMAD1. GDF-2 Protein, Human (P. pastoris, His) is the recombinant human-derived GDF-2 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of GDF-2 Protein, Human (P. pastoris, His) is 130 a.a., with molecular weight of 16.3 kDa.
Cat. No. Product Name Effect Purity