2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. EGF Superfamily
  5. Epiregulin

Epiregulin

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Epiregulin is member of the epidermal growth factor (EGF) family which is a 46-amino-acid single chain polypeptide, and its amino acid sequence exhibited 24-50% amino acid sequence identity with sequences of other EGF-related growth factors. Epiregulin binds to the EGF receptor EGFR and ErbB4 and can stimulate signaling of ErbB2 and ErbB3 through ligand-induced heterodimerization with a cognate receptor, leading to activation of downstream Ras-Raf-mitogen activated protein kinase (MAPK)-extracellular signal-regulated kinase (ERK) as well as the PI3K-Akt pathways to increase cellular proliferation. Epiregulin exhibited bifunctional regulatory properties: it inhibited the growth of several epithelial tumor cells and stimulated the growth of fibroblasts and various other types of cells. Epiregulin has been shown to promote wound healing in oral epithelium, enhance proliferation of other epithelial tissues, and is involved in several epithelial-related malignancies such as colorectal, lung, and bladder carcinoma.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P73031
    Epiregulin Protein, Human (HEK293, Fc)

    Proepiregulin; Epiregulin; EPR; EREG

    		Human HEK293
    Epiregulin Protein, a ligand for EGFR and ERBB4, crucially influences inflammation, wound healing, tissue repair, and oocyte maturation. It stimulates tyrosine phosphorylation of both receptors, regulating angiogenesis, vascular remodeling, and cell proliferation. Interactions with EGFR and ERBB4 contribute to intricate signaling pathways, essential for diverse physiological responses and cellular functions. Epiregulin Protein, Human (HEK293, Fc) is the recombinant human-derived Epiregulin protein, expressed by HEK293 , with N-hFc labeled tag.
  • HY-P75226
    Epiregulin Protein, Mouse (HEK293, hFc)

    Proepiregulin; Epiregulin; EPR; EREG

    		Mouse HEK293
    Epiregulin Protein, a ligand for EGFR and ERBB4, induces their tyrosine phosphorylation, playing a pivotal role in inflammation, wound healing, tissue repair, and oocyte maturation. It regulates angiogenesis, vascular remodeling, and cell proliferation, emphasizing its involvement in intricate cellular signaling pathways. Epiregulin Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived Epiregulin protein, expressed by HEK293 , with N-hFc labeled tag. The total length of Epiregulin Protein, Mouse (HEK293, hFc) is 46 a.a., with molecular weight of ~37 kDa.
  • HY-P7011
    Epiregulin Protein, Human

    rHuEpiregulin; EREG; EPR

    		Human E. coli
    Epiregulin Protein, Human is a growth regulator and a member of the epidermal growth factor (EGF) family. Epiregulin is a tumor growth-inhibitory factor inducing morphological changes in human epidermoid carcinoma HeLa cells.
Cat. No. Product Name Effect Purity