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  4. Interferon & Receptors
  5. IFN-alpha
  6. IFN-alpha 14

IFN-alpha 14

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IFN-alpha 14 (IFNA14; IFN-α14), belongs to the alpha/beta interferon (IFN) family, is produced by the macrophages with antiviral activities[1]. Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively[2]. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Interferon alpha (IFNa) shows significant biological activity in various cancers, paticularly haematological malignancies such as hairy cell leukaemia and chronic myelogenous leukaemia[3]. IFNα-14 involves in JAK/STAT signaling pathway, is identified as potent regulators that reduces both CTLA4 and FOXP3. Therefore, regulatory T cells (Tregs) as the key cells regulating peripheral autoreactive T lymphocytes, IFNα-14 regulates Treg functional states and destabilises Treg[4]. IFN-alpha14 is a new gene found in tissues of uninfected mice, also found to lack N-glycosylation and have its expression induced in response to viral infection in contrast to IFN-alpha 13[5].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P76401
    IFN-alpha 14/IFNA14 Protein, Mouse (HEK293, His)

    Interferon alpha-14; Interferon alpha-H; LeIF H; Interferon lambda-2-H; IFNA14

    		Mouse HEK293
    IFN-alpha 14 (IFNA14), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 14/IFNA14 Protein, Mouse (HEK293, His) contains 166 a.a. (C24-K189), produced in HEK293 cells with a C-terminal His-tag.
  • HY-P72243
    IFN-alpha 14/IFNA14 Protein, Human (His-SUMO)

    IFN-alpha14; IFN14_HUMAN; IFNA14; Interferon alpha 14; Interferon alpha H; Interferon alpha-14; Interferon alpha-H; Interferon lambda-2-H; Interferon lambda2H ; LeIF H; LeIFH; MGC125756; MGC125757

    		Human E. coli
    IFN-alpha 14 (IFNA14), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 14/IFNA14 Protein, Human (His-SUMO) contains 166 a.a. (C24-D189), produced in E. coli cells with a N-terminal His-SUMO tag.
  • HY-P76400
    IFN-alpha 14/IFNA14 Protein, Mouse (HEK293, Fc)

    Interferon alpha-14; Interferon alpha-H; LeIF H; Interferon lambda-2-H; IFNA14

    		Mouse HEK293
    IFN-alpha 14 (IFNA14), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 14/IFNA14 Protein, Mouse (HEK293, Fc) contains 166 a.a. (C24-K189), produced in HEK293 cells with a N-terminal hFc-tag.
  • HY-P77390
    IFN-alpha 14/IFNA14 Protein, Rhesus Macaque (P.pastoris, His)

    Interferon alpha-14; Interferon alpha-H; LeIF H; Interferon lambda-2-H; IFNA14

    		Rhesus Macaque P. pastoris
    IFN-alpha 14 (IFNA14), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 14/IFNA14 Protein, Rhesus Macaque (P.pastoris, His) contains 166 a.a. (C24-D189), produced in P.pastoris yeast cells with a C-terminal His-tag.
Cat. No. Product Name Effect Purity