2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Chemokine & Receptors
  5. CC Chemokines
  6. MIP-3 alpha/CCL20

MIP-3 alpha/CCL20

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CCL20, also known as macrophage inflammatory protein 3 alpha (MIP-3-alpha) and liver-activated regulatory chemokine (LARC), is a small cytokine belonging to the CC chemokine family and is located on chromosome 2 in the human genome. It is expressed at lower levels in the thymus, testis, prostate and intestine. CCL20 binds to and acts as a chemokine receptor CCR6 and synergistically inhibits the function of CD8 T cells with CCR6. CCL20 has antimicrobial activity and has been implicated in autoimmune diseases such as inflammatory bowel disease, rheumatoid arthritis, and psoriasis, as well as oncological diseases. It can induce Tregs to invade tumor tissue, recruit dendritic cells to promote immunosuppression, and induce endothelial cell proliferation and neointima formation[1][2].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P7260
    MIP-3 alpha/CCL20 Protein, Human (CHO)

    rHuMIP-3α/CCL20; C-C motif chemokine 20; MIP3A; SCYA20

    		Human CHO
    MIP-3 alpha/CCL20 Protein, Human (CHO) is a CC chemokine that attracts lymphocytes and mild neutrophils by binding to and acting on the chemokine receptor CCR6. It induces intracellular calcium mobilization and mediates cancer, various autoimmune diseases, and antimicrobial effects. MIP-3 alpha/CCL20 Protein, Human (CHO) is a recombinant human CCL20 (A27-M96) expressed by CHO cells.
  • HY-P7262
    MIP-3 alpha/CCL20 Protein, Human

    rHuMIP-3α/CCL20; C-C motif chemokine 20; MIP3A; SCYA20

    		Human E. coli
    MIP-3 alpha/CCL20 Protein, Human is a CC chemokine that attracts lymphocytes and mild neutrophils by binding to and acting on the chemokine receptor CCR6. It induces intracellular calcium mobilization and mediates cancer, various autoimmune diseases, and antimicrobial effects. MIP-3 alpha/CCL20 Protein, Human  is a recombinant human CCL20 (A27-M96) expressed by E. coli.
  • HY-P7263
    MIP-3 alpha/CCL20 Protein, Mouse

    rMuMIP-3α/CCL20; C-C motif chemokine 20; MIP3A; SCYA20

    		Mouse E. coli
    MIP-3 alpha/CCL20 Protein, Mouse is a CC chemokine that attracts lymphocytes and mild neutrophils by binding to and acting on the chemokine receptor CCR6. It induces intracellular calcium mobilization and mediates cancer, various autoimmune diseases, and antimicrobial effects. MIP-3 alpha/CCL20 Protein, Mouse  is a recombinant mouse CCL20 (A28-M97) expressed by E. coli.
  • HY-P7261
    MIP-3 alpha/CCL20 Protein, Rat (HEK293)

    rRtMIP-3α/CCL20; C-C motif chemokine 20; MIP3A; SCYA20

    		Rat HEK293
    MIP-3 alpha/CCL20 Protein, Rat (HEK293) is a CC chemokine that attracts lymphocytes and mild neutrophils by binding to and acting on the chemokine receptor CCR6. It induces intracellular calcium mobilization and mediates cancer, various autoimmune diseases, and antimicrobial effects. MIP-3 alpha/CCL20 Protein,  Rat (HEK293) is a recombinant rat CCL20 (A26-M96) expressed by HEK293 cells.
  • HY-P73813
    MIP-3 alpha/CCL20 Protein, Mouse (sf9, His)

    C-C motif chemokine 20; MIP3A; SCYA20

    		Mouse Sf9 insect cells
    MIP-3 alpha/CCL20 Protein, Mouse (sf9, His) is a CC chemokine that attracts lymphocytes and mild neutrophils by binding to and acting on the chemokine receptor CCR6. It induces intracellular calcium mobilization and mediates cancer, various autoimmune diseases, and antimicrobial effects. MIP-3 alpha/CCL20 Protein, Mouse (sf9, His) is a recombinant mouse CCL20 expressed by Sf9 insect cells with a his tag at the C-terminus.
  • HY-P73814
    MIP-3 alpha/CCL20 Protein, Human (His)

    C-C motif chemokine 20; MIP3A; SCYA20

    		Human E. coli
    MIP-3 alpha/CCL20 Protein, Human (His) is a CC chemokine that attracts lymphocytes and mild neutrophils by binding to and acting on the chemokine receptor CCR6. It induces intracellular calcium mobilization and mediates cancer, various autoimmune diseases, and antimicrobial effects. MIP-3 alpha/CCL20 Protein, Human (His) is a recombinant human CCL20 (A27-M96) expressed by E. coli  with a His tag at the C-terminus.
  • HY-P700551
    MIP-3 alpha/CCL20 Protein, Bovine (P. pastoris, His)

    rHuMIP-3α/CCL20; C-C motif chemokine 20; MIP3A; SCYA20

    		Bovine P. pastoris
    MIP-3 alpha/CCL20 Protein acts as a ligand for CCR6, inducing a potent chemotactic response and intracellular calcium mobilization upon CCR6 binding. Crucial in chemotaxis, the CCL20-CCR6 pair attracts dendritic cells, effector/memory T-cells, and B-cells, especially in skin and mucosal surfaces during homeostasis, inflammation, cancer, and autoimmune diseases. As a chemotactic factor, CCL20 selectively attracts lymphocytes, less so neutrophils, excluding monocytes. It recruits pro-inflammatory IL17-producing helper T-cells (Th17) and regulatory T-cells (Treg) to inflammation sites and is essential for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells. Additionally, it positively regulates sperm motility and chemotaxis by binding to CCR6, triggering Ca2+ mobilization in sperm for motility. CCL20 may contribute to the formation and function of mucosal lymphoid tissues by directing lymphocytes and dendritic cells to epithelial cells. MIP-3 alpha/CCL20 Protein, Bovine (P. pastoris, His) is the recombinant bovine-derived MIP-3 alpha/CCL20 protein, expressed by P. pastoris, with N-6*His labeled tag. The total length of MIP-3 alpha/CCL20 Protein, Bovine (P. pastoris, His) is 70 a.a., with molecular weight of 10.1 kDa.
  • HY-P700549
    MIP-3 alpha/CCL20 Protein, Rhesus macaque (GST)

    rHuMIP-3α/CCL20; C-C motif chemokine 20; MIP3A; SCYA20

    		Rhesus Macaque E. coli
    MIP-3 alpha/CCL20 Protein, part of the intercrine beta (chemokine CC) family, is instrumental in regulating immune cell migration and inflammation. Recognized for attracting and activating dendritic cells and memory T cells, it plays a vital role in immune response at infection or inflammation sites. Operating via its receptor CCR6, MIP-3 alpha/CCL20 initiates events that enhance immune cell recruitment and activation. As a potential therapeutic target, it holds promise for immune response modulation and inflammation control in diverse pathological conditions. MIP-3 alpha/CCL20 Protein, Rhesus macaque (GST) is the recombinant Rhesus Macaque-derived MIP-3 alpha/CCL20 protein, expressed by E. coli, with N-GST labeled tag. The total length of MIP-3 alpha/CCL20 Protein, Rhesus macaque (GST) is 70 a.a., with molecular weight of 35.1 kDa.
  • HY-P700550
    MIP-3 alpha/CCL20 Protein, Bovine (His-SUMO)

    rHuMIP-3α/CCL20; C-C motif chemokine 20; MIP3A; SCYA20

    		Bovine E. coli
    MIP-3 alpha/CCL20 Protein acts as a ligand for CCR6, inducing a potent chemotactic response and intracellular calcium mobilization upon CCR6 binding. Crucial in chemotaxis, the CCL20-CCR6 pair attracts dendritic cells, effector/memory T-cells, and B-cells, especially in skin and mucosal surfaces during homeostasis, inflammation, cancer, and autoimmune diseases. As a chemotactic factor, CCL20 selectively attracts lymphocytes, less so neutrophils, excluding monocytes. It recruits pro-inflammatory IL17-producing helper T-cells (Th17) and regulatory T-cells (Treg) to inflammation sites and is essential for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells. Additionally, it positively regulates sperm motility and chemotaxis by binding to CCR6, triggering Ca2+ mobilization in sperm for motility. CCL20 may contribute to the formation and function of mucosal lymphoid tissues by directing lymphocytes and dendritic cells to epithelial cells. MIP-3 alpha/CCL20 Protein, Bovine (His-SUMO) is the recombinant bovine-derived MIP-3 alpha/CCL20 protein, expressed by E. coli, with N-SUMO, N-6*His labeled tag. The total length of MIP-3 alpha/CCL20 Protein, Bovine (His-SUMO) is 70 a.a., with molecular weight of 24.1 kDa.
Cat. No. Product Name Effect Purity