Protoporphyrin IX disodium

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Protoporphyrin IX disodium is a final intermediate in the heme biosynthetic pathway, which acts as a radiation sensitizer enhancing ROS generation even in a hypoxic state and inducing DNA damage. Protoporphyrin IX disodium also acts as a photo sensitizer undergoing photobleaching that occurs through direct degradation by light irradiation. Protoporphyrin IX disodium is formed and accumulated following 5-aminolevulinic acid (5-ALA) (HY-W000450) administration in the tumor cells of rats. Protoporphyrin IX disodium causes selective improvement of basal cell carcinoma when activated red fluorescence of a peak wavelength at 405 nm. Protoporphyrin IX disodium is promising for research of sonodynamic and photodynamic agents for a wide range of cancers, such as bladder cancer and nodular basal cell carcinoma.

For research use only. We do not sell to patients.

Protoporphyrin IX disodium Chemical Structure

CAS No. : 50865-01-5

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Other In-stock Forms of Protoporphyrin IX disodium:

Protoporphyrin IX

Other Forms of Protoporphyrin IX disodium:

Protoporphyrin IX In-stock

15 Publications Citing Use of MCE Protoporphyrin IX disodium

: Protoporphyrin IX disodium purchased from MedChemExpress. Usage Cited in: Genome Biol. 2022 Dec 15;23(1):259. [Abstract]; Protoporphyrin IX (PpIX; 0, 5, 15, 25 µM; 2 h) rapidly results in increased nuclear G4 levels in HeLa cells. Immunostaining of G4 using BG4-EGFP (green). The nuclei are stained with DAPI (blue).

: Protoporphyrin IX disodium purchased from MedChemExpress. Usage Cited in: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 Jul;27(7):568-73. [Abstract]; To determine whether the inhibition of caveolin-1 tyrosine residues 14 ( Cav-1-Y14 ) phosphorylation with protein tyrosine kinase inhibitors ( PP2 ) will upregulate heme oxygenase-1 ( HO-1 ) activity to protect against ventilation induced lung injury in vivo of an animal model. The group D1 or D2 receive high tidal volume ventilation for 1 hour or 2 hour respectively, but they are given PP2 1 hour before high tidal volume ventilation. The groups E1 and E2 also receive high tidal volume ventilat

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Purity & Documentation
References
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Description

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

Protoporphyrin IX disodium (3.6 nmol/g tissue) tissue can cause necrosis in normal rat colonic mucosa on exposure to light^[4].
Protoporphyrin IX disodium (6.6 nmol/g tumor) delays tumor growth after irradiation of a tumor in rats^[4].
Protoporphyrin IX disodium (0-25 μM, 2 h) rapidly results in increased nuclear G4 levels in Hela cells^[5]。

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The highest level of Protoporphyrin IX disodium (approximately 6.3 nmol/g tissue) is found in rat liver and intestine, followed by aorta (4.3 nmol/g tissue) and oesophagus (2.1 nmol/g tissue), 3 h after Aminolevulinic acid (300 mg/kg, i.v., a single dose) administration^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

606.62

Formula

C₃₄H₃₂N₄Na₂O₄

CAS No.

50865-01-5

SMILES

O=C(O[Na])CCC1=C2/C=C3C(CCC(O[Na])=O)=C(C)C(/C=C(N/4)/C(C)=C(C=C)C4=C\C5=N/C(C(C=C)=C5C)=C\C(N2)=C1C)=N/3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yasushi Nakai, et al.Protoporphyrin IX induced by 5-aminolevulinic acid in bladder cancer cells in voided urine can be extracorporeally quantified using a spectrophotometer.

[2]. Myrzakhmetov B, et al. Photophysical Properties of Protoporphyrin IX, Pyropheophorbide-a and Photofrin^® in Different Conditions. Pharmaceuticals (Basel). 2021 Feb 9;14(2):138. [Content Brief]

[3]. Tope WD, et al. Protoporphyrin IX fluorescence induced in basal cell carcinoma by oral delta-aminolevulinic acid[J]. Photochem Photobiol. 1998 Feb;67(2):249-55. [Content Brief]

[4]. van den Boogert J, et al. 5-Aminolaevulinic acid-induced protoporphyrin IX accumulation in tissues: pharmacokinetics after oral or intravenous administration[J]. J Photochem Photobiol B. 1998 Jun 15;44(1):29-38. [Content Brief]

[5]. Li C, et al. G-quadruplexes sense natural porphyrin metabolites for regulation of gene transcription and chromatin landscapes. Genome Biol. 2022 Dec 15;23(1):259. [Content Brief]