PSB-1410

Cat. No.: HY-123665 Purity: 99.22%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

PSB-1410 is a selective and competitive monoamine oxidase B (MAO-B) inhibitor with IC₅₀ for human MAO-B and rat MAO-B Values are 0.23 and 1.01 nM respectively.

For research use only. We do not sell to patients.

PSB-1410 Chemical Structure

CAS No. : 1494477-03-0

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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MAO-A MAO-B

Biological Activity
Purity & Documentation
References
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Description

PSB-1410 is a selective and competitive monoamine oxidase B (MAO-B) inhibitor with IC₅₀ for human MAO-B and rat MAO-B Values are 0.23 and 1.01 nM respectively^[1].

IC₅₀ & Target

hMAO-B

0.23 nM (IC₅₀)

rMAO-B

1.01 nM (IC₅₀)

Molecular Weight

305.16

Formula

C₁₅H₁₀Cl₂N₂O

CAS No.

1494477-03-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC2=C(NC=C2)C=C1)NC3=CC=C(Cl)C(Cl)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (409.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2770 mL	16.3848 mL	32.7697 mL
5 mM	0.6554 mL	3.2770 mL	6.5539 mL
10 mM	0.3277 mL	1.6385 mL	3.2770 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.22%

Select Batch:

Data Sheet (270 KB) SDS (251 KB)

COA (248 KB) HNMR (245 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. Tzvetkov NT, et al. Indazole- and indole-5-carboxamides: selective and reversible monoamine oxidase B inhibitors with subnanomolar potency. J Med Chem. 2014 Aug 14;57(15):6679-703. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2770 mL	16.3848 mL	32.7697 mL	81.9242 mL
	5 mM	0.6554 mL	3.2770 mL	6.5539 mL	16.3848 mL
	10 mM	0.3277 mL	1.6385 mL	3.2770 mL	8.1924 mL
	15 mM	0.2185 mL	1.0923 mL	2.1846 mL	5.4616 mL
	20 mM	0.1638 mL	0.8192 mL	1.6385 mL	4.0962 mL
	25 mM	0.1311 mL	0.6554 mL	1.3108 mL	3.2770 mL
	30 mM	0.1092 mL	0.5462 mL	1.0923 mL	2.7308 mL
	40 mM	0.0819 mL	0.4096 mL	0.8192 mL	2.0481 mL
	50 mM	0.0655 mL	0.3277 mL	0.6554 mL	1.6385 mL
	60 mM	0.0546 mL	0.2731 mL	0.5462 mL	1.3654 mL
	80 mM	0.0410 mL	0.2048 mL	0.4096 mL	1.0241 mL
	100 mM	0.0328 mL	0.1638 mL	0.3277 mL	0.8192 mL

PSB-1410 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PSB-14101494477-03-0PSB1410PSB 1410Monoamine OxidaseMAONTZ-1010MAO-BInhibitorinhibitorinhibit

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