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PSB-CB5 is a potent and selective antagonist of GRP18. PSB-CB5 has the potential for the research of metabolic disease and obesity.

For research use only. We do not sell to patients.

PSB-CB5 Chemical Structure

PSB-CB5 Chemical Structure

CAS No. : 1627710-30-8

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Based on 1 publication(s) in Google Scholar

PSB-CB5 Related Antibodies

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Description

PSB-CB5 is a potent and selective antagonist of GRP18. PSB-CB5 has the potential for the research of metabolic disease and obesity[1].

Cellular Effect
Cell Line Type Value Description References
CHO IC50
> 10 μM
Compound: 32
Antagonist activity against human GPR55 expressed in CHO cells assessed as reduction in LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method
Antagonist activity against human GPR55 expressed in CHO cells assessed as reduction in LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method
10.1039/C3MD00394A
CHO IC50
0.279 μM
Compound: 32
Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method
Antagonist activity against human GPR18 expressed in CHO cells assessed as reduction in delta9-THC-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method
10.1039/C3MD00394A
Molecular Weight

384.88

Formula

C20H17ClN2O2S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N1C(SCCC1)=N/2)C2=C\C3=CC=CC(OCC4=CC=C(Cl)C=C4)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 2 mg/mL (5.20 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5982 mL 12.9911 mL 25.9821 mL
5 mM 0.5196 mL 2.5982 mL 5.1964 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Purity & Documentation

Purity: ≥95.0%

SDS (251 KB)

COA (245 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5982 mL 12.9911 mL 25.9821 mL 64.9553 mL
5 mM 0.5196 mL 2.5982 mL 5.1964 mL 12.9911 mL
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PSB-CB5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PSB-CB51627710-30-8OthersGRP18metabolic diseaseobesityInhibitorinhibitorinhibit

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