Pseudolycorine

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Pseudolycorine is an Amaryllidaceae alkaloid with anticancer activity.

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Pseudolycorine Chemical Structure

CAS No. : 29429-03-6

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Description

Pseudolycorine is an Amaryllidaceae alkaloid with anticancer activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	7.4 μM Compound: 3	Cytotoxicity against human A549 cells after 72 hrs by MTT colorimetric assay Cytotoxicity against human A549 cells after 72 hrs by MTT colorimetric assay	[PMID: 20550100]
A549	IC₅₀	7.5 μM Compound: 18, pseudolycorine	Growth inhibition of proapoptotic stimuli-resistant human A549 cells after 72 hrs by MTT assay Growth inhibition of proapoptotic stimuli-resistant human A549 cells after 72 hrs by MTT assay	[PMID: 19788245]
B16-F10	IC₅₀	7.5 μM Compound: 18, pseudolycorine	Growth inhibition of proapoptotic stimuli-sensitive mouse B16F10 cells after 72 hrs by MTT assay Growth inhibition of proapoptotic stimuli-sensitive mouse B16F10 cells after 72 hrs by MTT assay	[PMID: 19788245]
B16-F10	IC₅₀	7.5 μM Compound: 3	Cytotoxicity against mouse B16F10 cells after 72 hrs by MTT colorimetric assay Cytotoxicity against mouse B16F10 cells after 72 hrs by MTT colorimetric assay	[PMID: 20550100]
Hs 683	IC₅₀	7.9 μM Compound: 18, pseudolycorine	Growth inhibition of proapoptotic stimuli-sensitive human Hs683 cells after 72 hrs by MTT assay Growth inhibition of proapoptotic stimuli-sensitive human Hs683 cells after 72 hrs by MTT assay	[PMID: 19788245]
Hs 683	IC₅₀	7.9 μM Compound: 3	Cytotoxicity against human Hs683 cells after 72 hrs by MTT colorimetric assay Cytotoxicity against human Hs683 cells after 72 hrs by MTT colorimetric assay	[PMID: 20550100]
NHDF	IC₅₀	66.9 μM Compound: 18, pseudolycorine	Growth inhibition of human NHDF after 72 hrs by MTT assay Growth inhibition of human NHDF after 72 hrs by MTT assay	[PMID: 19788245]
SK-MEL	IC₅₀	> 10 μM Compound: 3	Cytotoxicity against human SK-MEL cells after 72 hrs by MTT colorimetric assay Cytotoxicity against human SK-MEL cells after 72 hrs by MTT colorimetric assay	[PMID: 20550100]
SK-MEL-28	IC₅₀	> 10 μM Compound: 18, pseudolycorine	Growth inhibition of proapoptotic stimuli-resistant human SK-MEL-28 cells after 72 hrs by MTT assay Growth inhibition of proapoptotic stimuli-resistant human SK-MEL-28 cells after 72 hrs by MTT assay	[PMID: 19788245]
U-373MG ATCC	IC₅₀	7.8 μM Compound: 18, pseudolycorine	Growth inhibition of proapoptotic stimuli-resistant human U373 cells after 72 hrs by MTT assay Growth inhibition of proapoptotic stimuli-resistant human U373 cells after 72 hrs by MTT assay	[PMID: 19788245]
U-373MG ATCC	IC₅₀	7.8 μM Compound: 3	Cytotoxicity against human U373 cells after 72 hrs by MTT colorimetric assay Cytotoxicity against human U373 cells after 72 hrs by MTT colorimetric assay	[PMID: 20550100]
Vero	IC₅₀	0.28 μg/mL Compound: 17	Antiviral activity against Japanese encephalitis virus Nakayama infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay Antiviral activity against Japanese encephalitis virus Nakayama infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay	[PMID: 1336040]
Vero	IC₅₀	0.35 μg/mL Compound: 17	Antiviral activity against Yellow fever virus Ashibi infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay Antiviral activity against Yellow fever virus Ashibi infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay	[PMID: 1336040]
Vero	IC₅₀	0.39 μg/mL Compound: 17	Antiviral activity against Dengue virus type 4 infected in african green monkey Vero cells after 6 days by plaque reduction assay Antiviral activity against Dengue virus type 4 infected in african green monkey Vero cells after 6 days by plaque reduction assay	[PMID: 1336040]
Vero	IC₅₀	0.6 μg/mL Compound: 17	Antiviral activity against Punta Toro virus Adames infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay Antiviral activity against Punta Toro virus Adames infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay	[PMID: 1336040]
Vero	IC₅₀	0.63 μg/mL Compound: 17	Antiviral activity against Rift Valley fever virus infected in african green monkey Vero cells after 6 days by plaque reduction assay Antiviral activity against Rift Valley fever virus infected in african green monkey Vero cells after 6 days by plaque reduction assay	[PMID: 1336040]
WI-38	IC₅₀	44 μM Compound: 18, pseudolycorine	Growth inhibition of human WI38 cells after 72 hrs by MTT assay Growth inhibition of human WI38 cells after 72 hrs by MTT assay	[PMID: 19788245]

In Vitro

Pseudolycorine shows growth-inhibitory activity, with IC₅₀ values of 7.4 μM, 7.9 μM, 7.9 μM, 7.8 μM, and 7.5 μM for A549, OE21, Hs683, U373, and B16F10 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

289.33

Formula

C₁₆H₁₉NO₄

CAS No.

29429-03-6

SMILES

O[C@@H]1[C@@H](O)C=C(CC2)[C@@]3([H])N2CC4=C([C@@]31[H])C=C(O)C(OC)=C4

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gwendoline Van Goietsenoven, et al. Amaryllidaceae alkaloids belonging to different structural subgroups display activity against apoptosis-resistant cancer cells. J Nat Prod. 2010 Jul 23;73(7):1223-7. [Content Brief]

Pseudolycorine Related Classifications

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pseudolycorine29429-03-6OthersAmaryllidaceae alkaloidanticancer activityInhibitorinhibitorinhibit

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