Pseudouridine 5'-triphosphate (trisodium) solution (100mM)  (Synonyms: Pseudo-UTP (trisodium) solution (100mM))

Pseudouridine-5’-triphosphate (Pseudo-UTP) trisodium solution (100mM) is one of the most commonly used modified nucleoside for the polymerase-mediated synthesis of RNA molecules. Compared with uridine-containing unmodified mRNAs, the application of pseudouridine-containing modified mRNAs exhibits better nuclease stability, immunogenicity, and translational properties^[1].
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550.09

C₉H₁₂N₂Na₃O₁₅P₃

Liquid

Colorless to light yellow

O=P(O)(O[Na])OP(OP(OC[C@H]1O[C@@H](C(C(N2)=O)=CNC2=O)[C@H](O)[C@@H]1O)(O[Na])=O)(O[Na])=O

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Muthian Shanmugasundaram, et al. An Efficient Protection-Free One-Pot Chemical Synthesis of Modified Nucleoside-5'-Triphosphates. Nucleosides Nucleotides Nucleic Acids. 2016 Jul 2;35(7):356-62.  [Content Brief]