Pseudouridine-O¹⁸

Cat. No.: HY-113061S: FAQs
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Pseudouridine-¹⁸O is the ¹⁸O labeled Pseudouridine (HY-113061). Pseudouridine is an isomer of the nucleoside uridine, and the most abundant modified nucleoside in non-coding RNAs. Pseudouridine in rRNA and tRNA can fine-tune and stabilize the regional structure and help maintain their functions in mRNA decoding, ribosome assembly, processing and translation.

For research use only. We do not sell to patients.

Pseudouridine-O<sup>18</sup> Chemical Structure

Pseudouridine-O¹⁸ Chemical Structure

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1 mg		Get quote	Estimated Time of Arrival: December 31

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Other Forms of Pseudouridine-O¹⁸:

Pseudouridine Get quote

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Description	Pseudouridine-¹⁸O is the ¹⁸O labeled Pseudouridine (HY-113061). Pseudouridine is an isomer of the nucleoside uridine, and the most abundant modified nucleoside in non-coding RNAs. Pseudouridine in rRNA and tRNA can fine-tune and stabilize the regional structure and help maintain their functions in mRNA decoding, ribosome assembly, processing and translation.
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Pseudouridine-O¹⁸ Related Antibodies
Molecular Weight	246.20
Formula	C₉H₁₂N₂O₅¹⁸O
Unlabeled CAS	1445-07-4
SMILES	O[C@H]1[C@@H](O)[C@H](C(C(N2)=O)=CNC2=O)O[C@@H]1C[18OH]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (272 KB) Handling Instructions (2659 KB)
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief] [2]. Carlile TM, et al. Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells. Nature. 2014 Nov 6;515(7525):143-6. [Content Brief] [3]. M Charette, et al. Pseudouridine in RNA: what, where, how, and why. IUBMB Life. 2000 May;49(5):341-51. [Content Brief] [4]. Junhui Ge, et al. RNA pseudouridylation: new insights into an old modification. Trends Biochem Sci. 2013 Apr;38(4):210-8. [Content Brief] [5]. Anne C Rintala-Dempsey, et al. Eukaryotic stand-alone pseudouridine synthases - RNA modifying enzymes and emerging regulators of gene expression? RNA Biol. 2017 Sep 2;14(9):1185-1196. [Content Brief]