PSMA-D5 

PSMA-D5 has a binding affinity for PSMA with K_i of 0.21 nM and can be used for PSMA tracing after radiolabeling. PSMA-D5 ([⁶⁸Ga]-labeled) contains a DOTA chelator, allowing convenient labeling with therapeutic radionuclides such as ¹⁷⁷Lu and ²²⁵Ac. PSMA-D5 ([⁶⁸Ga]-labeled) shows excellent pharmacokinetic properties, exhibiting remarkable tumor uptake in 22Rv1 tumors^[1].

PSMA-D5 ([⁶⁸Ga]-labeled) (1 h) exhibits superior uptake performance in PSMA-positive 22Rv1 cells (uptake value: 1.68)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PSMA-D5 ([68Ga]-labeled) (∼3.7 MBq, i.v.) shows high tumor uptake (SUV_max = 3.51) and better visualization of smaller lesions than PSMA-11 ([68Ga]-labeled) (T/M values: 32.01 and 26.8, respectively) in 22Rv1 tumors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1317.31

C₅₇H₈₀N₁₂O₂₄

3056440-83-3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Chen Y, et al. Synthesis, Preclinical Evaluation, and First-in-Human PET Study of [68Ga]-Labeled Biphenyl-Containing PSMA Tracers. J Med Chem. 2023 Sep 28;66(18):13332-13345.  [Content Brief]