2. Antibody-drug Conjugate/ADC Related Immunology/Inflammation
  3. Drug-Linker Conjugates for ADC PSMA
  4. PSMA-Val-Cit-PAB-Azide

PSMA-Val-Cit-PAB-Azide is a drug-linker conjugate for ADC. PSMA-Val-Cit-PAB-Azide contains the cleavable ADCs linker (Val-Cit-PAB) and a novel small-molecule PSMA-targeted conjugate. It contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups.

For research use only. We do not sell to patients.

PSMA-Val-Cit-PAB-Azide Chemical Structure

PSMA-Val-Cit-PAB-Azide Chemical Structure

CAS No. : 2374814-84-1

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1 mg USD 320 In-stock
5 mg USD 900 In-stock
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Based on 1 publication(s) in Google Scholar

PSMA-Val-Cit-PAB-Azide Related Antibodies

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Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

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Description

PSMA-Val-Cit-PAB-Azide is a drug-linker conjugate for ADC. PSMA-Val-Cit-PAB-Azide contains the cleavable ADCs linker (Val-Cit-PAB) and a novel small-molecule PSMA-targeted conjugate. It contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups[1].

IC50 & Target[1]

Traditional Cytotoxic Agents

 

Molecular Weight

1049.56

Formula

C50H65ClN10O13
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@H](C(NCCCN=[N+]=[N-])=O)CC(C=C1)=CC=C1O)[C@@H](NC(CCC(NCCCCCC(N(CCCC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O)CC2=CC(Cl)=CC=C2)=O)=O)=O)CC3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (190.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9528 mL 4.7639 mL 9.5278 mL
5 mM 0.1906 mL 0.9528 mL 1.9056 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9528 mL 4.7639 mL 9.5278 mL 23.8195 mL
5 mM 0.1906 mL 0.9528 mL 1.9056 mL 4.7639 mL
10 mM 0.0953 mL 0.4764 mL 0.9528 mL 2.3820 mL
15 mM 0.0635 mL 0.3176 mL 0.6352 mL 1.5880 mL
20 mM 0.0476 mL 0.2382 mL 0.4764 mL 1.1910 mL
25 mM 0.0381 mL 0.1906 mL 0.3811 mL 0.9528 mL
30 mM 0.0318 mL 0.1588 mL 0.3176 mL 0.7940 mL
40 mM 0.0238 mL 0.1191 mL 0.2382 mL 0.5955 mL
50 mM 0.0191 mL 0.0953 mL 0.1906 mL 0.4764 mL
60 mM 0.0159 mL 0.0794 mL 0.1588 mL 0.3970 mL
80 mM 0.0119 mL 0.0595 mL 0.1191 mL 0.2977 mL
100 mM 0.0095 mL 0.0476 mL 0.0953 mL 0.2382 mL
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PSMA-Val-Cit-PAB-Azide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PSMA-Val-Cit-PAB-Azide2374814-84-1Drug-Linker Conjugates for ADCPSMAProstate-specific membrane antigenCleavableVal-Cit-PABAzideCuAAcAlkyneInhibitorinhibitorinhibit

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