2. MAPK/ERK Pathway Metabolic Enzyme/Protease Cytoskeleton Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt
  3. JNK SGK ROCK
  4. PT109

PT109 is a multi-kinase inhibitor. PT109 inhibits JNK (JNK1: IC50=0.143 μM; JNK2: IC50=0.831 μM; JNK3: IC50=0.285 μM) and other kinases (SGK1: IC50=1.34 μM; SGK2: IC50=5.6 μM; SGK3: IC50=26.4 μM; ROCK2: IC50=34 μM) and plays an important role in anti-inflammation, anti-oxidation, neurogenesis, synaptogenesis, etc. In addition, PT109 also reprograms glioblastoma multiforme (GBM) into oligodendrocytes through the PTBP1/PKM1/2 pathway and changes the metabolic pattern of GBM, exerting anti-glioma activity.

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PT109 Chemical Structure

PT109 Chemical Structure

CAS No. : 2059104-90-2

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PT109 Related Antibodies

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Description

PT109 is a multi-kinase inhibitor. PT109 inhibits JNK (JNK1: IC50=0.143 μM; JNK2: IC50=0.831 μM; JNK3: IC50=0.285 μM) and other kinases (SGK1: IC50=1.34 μM; SGK2: IC50=5.6 μM; SGK3: IC50=26.4 μM; ROCK2: IC50=34 μM) and plays an important role in anti-inflammation, anti-oxidation, neurogenesis, synaptogenesis, etc. In addition, PT109 also reprograms glioblastoma multiforme (GBM) into oligodendrocytes through the PTBP1/PKM1/2 pathway and changes the metabolic pattern of GBM, exerting anti-glioma activity[1][2].

IC50 & Target[1]

JNK1

0.143 μM (IC50)

JNK2

0.831 μM (IC50)

JNK3

0.285 μM (IC50)

SGK1

1.34 μM (IC50)

SGK3

26.4 μM (IC50)

ROCK2

34 μM (IC50)

Molecular Weight

429.64

Formula

C23H31N3OS2
CAS No.
SMILES

O=C(CCCCC1SSCC1)NC2CCC(CC2)NC3=CC=CC4=C3C=CN=C4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PT109 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PT1092059104-90-2PT 109PT-109JNKSGKROCKc-Jun N-terminal kinaseSerum-glucocorticoid regulated kinaseSerum and glucocorticoid-regulated kinaseRho-associated protein kinaseRho-associated kinaseRho-kinaseROKKinaseInhibitorAnti-inflammatoryNeurogenesisglioblastomainhibitorinhibit

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