PTAD-PEG8-alkyne

Cat. No.: HY-164928: FAQs
Data Sheet Handling Instructions

Molarity Calculator

PTAD-PEG8-alkyne is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

PTAD-PEG8-alkyne Chemical Structure

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

PTAD-PEG8-alkyne is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1].

Molecular Weight

684.73

Formula

C₃₁H₄₈N₄O₁₃

Appearance

Oil

SMILES

COC1=C(OCCNC(CCOCCOCCOCCOCCOCCOCCOCCOCC#C)=O)C=CC(N2C(NNC2=O)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (182.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4604 mL	7.3021 mL	14.6043 mL
5 mM	0.2921 mL	1.4604 mL	2.9209 mL
10 mM	0.1460 mL	0.7302 mL	1.4604 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.4604 mL	7.3021 mL	14.6043 mL	36.5107 mL
	5 mM	0.2921 mL	1.4604 mL	2.9209 mL	7.3021 mL
	10 mM	0.1460 mL	0.7302 mL	1.4604 mL	3.6511 mL
	15 mM	0.0974 mL	0.4868 mL	0.9736 mL	2.4340 mL
	20 mM	0.0730 mL	0.3651 mL	0.7302 mL	1.8255 mL
	25 mM	0.0584 mL	0.2921 mL	0.5842 mL	1.4604 mL
	30 mM	0.0487 mL	0.2434 mL	0.4868 mL	1.2170 mL
	40 mM	0.0365 mL	0.1826 mL	0.3651 mL	0.9128 mL
	50 mM	0.0292 mL	0.1460 mL	0.2921 mL	0.7302 mL
	60 mM	0.0243 mL	0.1217 mL	0.2434 mL	0.6085 mL
	80 mM	0.0183 mL	0.0913 mL	0.1826 mL	0.4564 mL
	100 mM	0.0146 mL	0.0730 mL	0.1460 mL	0.3651 mL

PTAD-PEG8-alkyne Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PTAD-PEG8-alkyneADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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