2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. PTP1B-IN-21

PTP1B-IN-21 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B; IC50=1.56 μM) over the highly homologous T-cell protein tyrosine phosphatase (TCPTP; IC50>100 μM), which is a key target for type 2 diabetes inhibition.

For research use only. We do not sell to patients.

PTP1B-IN-21 Chemical Structure

PTP1B-IN-21 Chemical Structure

CAS No. : 3001295-85-5

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PTP1B-IN-21 Related Antibodies

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Description

PTP1B-IN-21 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B; IC50=1.56 μM) over the highly homologous T-cell protein tyrosine phosphatase (TCPTP; IC50>100 μM), which is a key target for type 2 diabetes inhibition[1].

IC50 & Target

IC50: 1.56 μM (PTP1B); >100 μM (TCPTP)[1]
In Vitro

PTP1B-IN-21 (compound 8) (0-100 μM; 15 min; 37 ℃) with 5,6-dihydroxyl groups is more potent against protein tyrosine phosphatase 1B[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PTP1B-IN-21 Related Antibodies
Molecular Weight

462.40

Formula

C22H22O11
CAS No.
SMILES

COC1=CC2=C(C(C3=C(C2=O)C=C(C(CO)=C3O)O[C@H]4[C@H](O)[C@H]([C@@H]([C@H](O4)CO)O)O)=O)C=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PTP1B-IN-21 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PTP1B-IN-213001295-85-5Phosphatasetype 2 diabetesanthraquinone glycosidesbioavailabilityInhibitorinhibitorinhibit

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