2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. PVP-037.2

PVP-037.2 is a TLR7/8 agonist. PVP-037.2 can serve as an adjuvant to enhance vaccine-induced TH1 type immune responses, increasing the production of antigen-specific antibodies IgG1 and IgG2c.

For research use only. We do not sell to patients.

PVP-037.2 Chemical Structure

PVP-037.2 Chemical Structure

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PVP-037.2 Related Antibodies

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Description

PVP-037.2 is a TLR7/8 agonist. PVP-037.2 can serve as an adjuvant to enhance vaccine-induced TH1 type immune responses, increasing the production of antigen-specific antibodies IgG1 and IgG2c[1].

IC50 & Target

TLR7

 

TLR8

 

In Vitro

PVP-037.2 (0.1-100 μM, 24 h) induces concentration-dependent production of TNF and IL-1β in human elder peripheral blood mononuclear cells (PBMCs)[1].
PVP-037.2 ((100 μM, 20-24 h) demonstrates a TLR7/8-dependent immunomodulatory profile[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PVP-037.2 Related Antibodies
In Vivo

PVP-037.2 (3 mg/kg, i.v., measured 0-8 hours post-administration) shows high plasma clearance and almost no hemolytic activity in adult C57BL/6J mice (20 to 30 g in weight)[1].
PVP-037.2 (100 nmol per mouse, i.v., single immunization) exhibits potent adjuvant effects in C57BL/6J mice immunized with the trivalent recombinant rHA influenza vaccine Flublok and SARS-CoV-2 spike protein[1].
Compared with the use of PVP-037.2 alone, the PVP-037.2 O/W emulsion formulation (10 nmol per mouse, i.v., IgG titer measured on day 42) enhances the innate immune activation capability in wild-type C57BL/6J mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: WT C57BL/6J mice
Dosage: 10 nmol per mouse
Administration: Intravenous injection (i.v.), single injection
Result: Significantly enhanced total IgG and IgG2c class-switched antibody responses (IgG titers measured on day 42).
Animal Model: C57BL/6J mice (6 to 8 weeks old, stimulated with the trivalent recombinant rHA influenza vaccine Flublok and the SARS-CoV-2 spike protein)
Dosage: 100 nmol per mouse
Administration: Intravenous injection (i.v.), single injection
Result: Resulted that the production of antigen-specific IgG1 and IgG2c was significantly enhanced in C57BL/6J mice stimulated with the trivalent recombinant rHA influenza vaccine Flublok (IgG titers measured on day 28) and the SARS-CoV-2 spike protein (IgG titers measured on day 42).
Molecular Weight

439.43

Formula

C23H20F3N5O
Appearance

Solid

Color

White to light yellow

SMILES

CC1=CN2C=C(N=C2N=C1)C3=CC(NC(C4=C(C=C(C=C4)CN)C(F)(F)F)=O)=C(C=C3)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (71.11 mM; ultrasonic and adjust pH to 7 with 1 M HCL; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2757 mL 11.3784 mL 22.7568 mL
5 mM 0.4551 mL 2.2757 mL 4.5514 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.18%

SDS (251 KB)

COA (249 KB) HNMR (332 KB) CNMR (264 KB) RP-HPLC (262 KB) LCMS (107 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2757 mL 11.3784 mL 22.7568 mL 56.8919 mL
5 mM 0.4551 mL 2.2757 mL 4.5514 mL 11.3784 mL
10 mM 0.2276 mL 1.1378 mL 2.2757 mL 5.6892 mL
15 mM 0.1517 mL 0.7586 mL 1.5171 mL 3.7928 mL
20 mM 0.1138 mL 0.5689 mL 1.1378 mL 2.8446 mL
25 mM 0.0910 mL 0.4551 mL 0.9103 mL 2.2757 mL
30 mM 0.0759 mL 0.3793 mL 0.7586 mL 1.8964 mL
40 mM 0.0569 mL 0.2845 mL 0.5689 mL 1.4223 mL
50 mM 0.0455 mL 0.2276 mL 0.4551 mL 1.1378 mL
60 mM 0.0379 mL 0.1896 mL 0.3793 mL 0.9482 mL
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PVP-037.2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PVP-037.2Toll-like Receptor (TLR)Peripheral blood mononuclear cells (PBMCs)C57BL/6J mice model (stimulated with the trivalent recombinant rHA influenza vaccine Flublok and the SARS-CoV-2 spike protein)AdjuvanticityInflammation/ImmunologyInhibitorinhibitorinhibit

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PVP-037.2
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