Pyridoxal phosphate-d₅

Name: Pyridoxal phosphate-d 5
Brand: MedChemExpress
SKU: HY-B1744S
Rating: 5.0 (1 reviews)

Cat. No.: HY-B1744S Purity: 99.30%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Pyridoxal phosphate-d₅ is the deuterium labeled Pyridoxal phosphate. Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia[1][2].

For research use only. We do not sell to patients.

Pyridoxal phosphate-d<sub>5</sub> Chemical Structure

Pyridoxal phosphate-d₅ Chemical Structure

CAS No. : 1246818-16-5

Size	Price	Stock	Quantity
500 μg	USD 1638	In-stock	Estimated Time of Arrival: December 31

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Based on 1 publication(s) in Google Scholar

Other Forms of Pyridoxal phosphate-d₅:

Pyridoxal phosphate In-stock

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Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

252.17

Formula

C₈H₅D₅NO₆P

CAS No.

1246818-16-5

Unlabeled CAS

54-47-7

Appearance

Solid

Color

White to light yellow

SMILES

C(OP(=O)(O)O)(C=1C(C=O)=C(O)C(C([2H])([2H])[2H])=NC1)([2H])[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL (247.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.9656 mL	19.8279 mL	39.6558 mL
5 mM	0.7931 mL	3.9656 mL	7.9312 mL
10 mM	0.3966 mL	1.9828 mL	3.9656 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.30%

Select Batch:

Data Sheet (275 KB) SDS (251 KB)

COA (252 KB) Elemental Analysis Report (111 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Modak MJ. Pyridoxal 5' phosphate: a selective inhibitor of oncornaviral DNA polymerases. Biochem Biophys Res Commun. 1976 Jul 12;71(1):180-7. [Content Brief]

[3]. Grin IR, et al. Inactivation of NEIL2 DNA glycosylase by pyridoxal phosphate reveals a loop important for substrate binding. Biochem Biophys Res Commun. 2010 Mar 26;394(1):100-5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.9656 mL	19.8279 mL	39.6558 mL	99.1395 mL
	5 mM	0.7931 mL	3.9656 mL	7.9312 mL	19.8279 mL
	10 mM	0.3966 mL	1.9828 mL	3.9656 mL	9.9139 mL
	15 mM	0.2644 mL	1.3219 mL	2.6437 mL	6.6093 mL
	20 mM	0.1983 mL	0.9914 mL	1.9828 mL	4.9570 mL
	25 mM	0.1586 mL	0.7931 mL	1.5862 mL	3.9656 mL
	30 mM	0.1322 mL	0.6609 mL	1.3219 mL	3.3046 mL
	40 mM	0.0991 mL	0.4957 mL	0.9914 mL	2.4785 mL
	50 mM	0.0793 mL	0.3966 mL	0.7931 mL	1.9828 mL
	60 mM	0.0661 mL	0.3305 mL	0.6609 mL	1.6523 mL
	80 mM	0.0496 mL	0.2478 mL	0.4957 mL	1.2392 mL
	100 mM	0.0397 mL	0.1983 mL	0.3966 mL	0.9914 mL