2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. PZ-II-029

PZ-II-029 is a GABAA positive allosteric modulator that selectively binds with high affinity to α6β3γ2. PZ-II-029 shows anti-migraine effects.

For research use only. We do not sell to patients.

PZ-II-029 Chemical Structure

PZ-II-029 Chemical Structure

CAS No. : 164025-44-9

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5 mg USD 140 In-stock
10 mg USD 220 In-stock
25 mg USD 390 In-stock
50 mg USD 600 In-stock
100 mg USD 920 In-stock
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Based on 1 publication(s) in Google Scholar

PZ-II-029 Related Antibodies

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Description

PZ-II-029 is a GABAA positive allosteric modulator that selectively binds with high affinity to α6β3γ2. PZ-II-029 shows anti-migraine effects[1].

In Vivo

PZ-II-029 (1-10 mg/kg; i.p.; 30 min before Capsaicin instillation) inhibits central and peripheral trigeminal responses in a rat migraine model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (250-300 g; 8-10 weeks) induced by intra-cisternal (i.c.) instillation of Capsaicin[1].
Dosage: 1, 3, or 10 mg/kg
Administration: i.p.; 30 min before Capsaicin instillation
Result: Significantly attenuated the trigeminal cervical complex (TCC) neuronal activation and trigeminal ganglia (TG) calcitonin gene-related peptide immunoreactivity (CGRP-ir) elevation, and dural CGRP depletion induced by capsaicin.
Molecular Weight

321.33

Formula

C18H15N3O3
CAS No.
Appearance

Solid

Color

Yellow to brown

SMILES

O=C1N(C2=CC=C(OC)C=C2)N=C3C1=CNC4=C3C=CC(OC)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (389.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1121 mL 15.5603 mL 31.1207 mL
5 mM 0.6224 mL 3.1121 mL 6.2241 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1121 mL 15.5603 mL 31.1207 mL 77.8016 mL
5 mM 0.6224 mL 3.1121 mL 6.2241 mL 15.5603 mL
10 mM 0.3112 mL 1.5560 mL 3.1121 mL 7.7802 mL
15 mM 0.2075 mL 1.0374 mL 2.0747 mL 5.1868 mL
20 mM 0.1556 mL 0.7780 mL 1.5560 mL 3.8901 mL
25 mM 0.1245 mL 0.6224 mL 1.2448 mL 3.1121 mL
30 mM 0.1037 mL 0.5187 mL 1.0374 mL 2.5934 mL
40 mM 0.0778 mL 0.3890 mL 0.7780 mL 1.9450 mL
50 mM 0.0622 mL 0.3112 mL 0.6224 mL 1.5560 mL
60 mM 0.0519 mL 0.2593 mL 0.5187 mL 1.2967 mL
80 mM 0.0389 mL 0.1945 mL 0.3890 mL 0.9725 mL
100 mM 0.0311 mL 0.1556 mL 0.3112 mL 0.7780 mL
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PZ-II-029 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PZ-II-029164025-44-9GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGABAA positive allosteric modulatoranti-migraine effectsα6β3γ2Inhibitorinhibitorinhibit

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