2. PROTAC Apoptosis
  3. PROTACs Bcl-2 Family
  4. PZ703b

PZ703b is a Bcl-xl PROTAC degrader that induces apoptosis and inhibits cancer cell proliferation. PZ703b can be used for the research of bladder cancer research.

For research use only. We do not sell to patients.

PZ703b Chemical Structure

PZ703b Chemical Structure

CAS No. : 2471970-56-4

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1 mg USD 1400 In-stock
5 mg USD 4200 In-stock
10 mg USD 6800 In-stock
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100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of PZ703b:

PZ703b Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE PZ703b

View All PROTACs Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All Bcl-2 Family Isoform Specific Products:

View All Isoforms
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PZ703b is a Bcl-xl PROTAC degrader that induces apoptosis and inhibits cancer cell proliferation. PZ703b can be used for the research of bladder cancer research[1][2].

IC50 & Target

VHL

 

Bcl-xL

 

In Vitro

PZ703b (0-1 μM, 24 h) synergistically inhibits bladder cancer cell proliferation with Mivebresib with a dose-dependent manner and induces apoptosis in bladder cancer cells via the mitochondrial pathway[1].
PZ703b (0-1 μM, 48 h) inhibits cell viability of MOLT-4 and RS4;11 cells with IC50 values of 15.9 and 11.3 nM, respectively[2].
PZ703b (10 nM, 48 h) induces rapid and durable BCL-XL degradation and apoptosis in MOLT-4 cells through the caspase-3 mediated pathway[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PZ703b Related Antibodies

Cell Viability Assay[1]

Cell Line: MOLT-4 cell line
Concentration: 10 nM
Incubation Time: 48 hours
Result: Induced cell apoptosis of MOLT-4 cells.
Molecular Weight

1600.43

Formula

C80H102ClF3N10O11S4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC1=CC=C(C=C1)C2=C(C[C@](CNC(CCCCCCCCC(N[C@H](C(N3C[C@@H](C[C@H]3C(N[C@@H](C)C4=CC=C(C=C4)C5=C(N=CS5)C)=O)O)=O)C(C)(C)C)=O)=O)(CC2)C)CN6CCN(CC6)C7=CC=C(C=C7)C(NS(C8=CC(S(=O)(C(F)(F)F)=O)=C(C=C8)N[C@H](CCN9CCOCC9)CSC%10=CC=CC=C%10)(=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (62.48 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6248 mL 3.1242 mL 6.2483 mL
5 mM 0.1250 mL 0.6248 mL 1.2497 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6248 mL 3.1242 mL 6.2483 mL 15.6208 mL
5 mM 0.1250 mL 0.6248 mL 1.2497 mL 3.1242 mL
10 mM 0.0625 mL 0.3124 mL 0.6248 mL 1.5621 mL
15 mM 0.0417 mL 0.2083 mL 0.4166 mL 1.0414 mL
20 mM 0.0312 mL 0.1562 mL 0.3124 mL 0.7810 mL
25 mM 0.0250 mL 0.1250 mL 0.2499 mL 0.6248 mL
30 mM 0.0208 mL 0.1041 mL 0.2083 mL 0.5207 mL
40 mM 0.0156 mL 0.0781 mL 0.1562 mL 0.3905 mL
50 mM 0.0125 mL 0.0625 mL 0.1250 mL 0.3124 mL
60 mM 0.0104 mL 0.0521 mL 0.1041 mL 0.2603 mL
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PZ703b Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PZ703b2471970-56-4PROTACsBcl-2 FamilyPROTACapoptosiscancerbladder cancerMOLT-4RS4;11Inhibitorinhibitorinhibit

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