QL47R

Cat. No.: HY-160245 Purity: 99.94%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

QL47R is an approximately isosteric analogue of QL47 (HY-80003). QL47R dose not inhibit the biochemical kinase activity of BTK at concentrations below 10 μM. QL47R dose not display antiproliferative activity on B-Cell Lymphoma Cell Lines at concentrations of less than 10 μM.

For research use only. We do not sell to patients.

QL47R Chemical Structure

CAS No. : 1579278-89-9

Size	Price	Stock	Quantity
1 mg	USD 495	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1235	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1975	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Description

Molecular Weight

449.50

Formula

C₂₇H₂₃N₅O₂

CAS No.

1579278-89-9

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1C=CC2=CN=C3C=CC(C4=CN(C)N=C4)=CC3=C2N1C5=CC=C6C(N(CC6)C(CC)=O)=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (222.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2247 mL	11.1235 mL	22.2469 mL
5 mM	0.4449 mL	2.2247 mL	4.4494 mL
10 mM	0.2225 mL	1.1123 mL	2.2247 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.94%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (259 KB) HNMR (167 KB) RP-HPLC (237 KB) LCMS (91 KB)

Handling Instructions (2659 KB)

References

[1]. Wu H, et al. Discovery of a potent, covalent BTK inhibitor for B-cell lymphoma. ACS Chem Biol. 2014 May 16;9(5):1086-91. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2247 mL	11.1235 mL	22.2469 mL	55.6174 mL
	5 mM	0.4449 mL	2.2247 mL	4.4494 mL	11.1235 mL
	10 mM	0.2225 mL	1.1123 mL	2.2247 mL	5.5617 mL
	15 mM	0.1483 mL	0.7416 mL	1.4831 mL	3.7078 mL
	20 mM	0.1112 mL	0.5562 mL	1.1123 mL	2.7809 mL
	25 mM	0.0890 mL	0.4449 mL	0.8899 mL	2.2247 mL
	30 mM	0.0742 mL	0.3708 mL	0.7416 mL	1.8539 mL
	40 mM	0.0556 mL	0.2781 mL	0.5562 mL	1.3904 mL
	50 mM	0.0445 mL	0.2225 mL	0.4449 mL	1.1123 mL
	60 mM	0.0371 mL	0.1854 mL	0.3708 mL	0.9270 mL
	80 mM	0.0278 mL	0.1390 mL	0.2781 mL	0.6952 mL
	100 mM	0.0222 mL	0.1112 mL	0.2225 mL	0.5562 mL

QL47R Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

QL47R1579278-89-9OthersInhibitorinhibitorinhibit

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