2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. QO-40

QO-40 is a pyrazolo[1,5-a]pyrimidine-7(4H)-one (PPO) derivative and an activator of the voltage-gated M-type potassium channel KCNQ encoded by the KCNQ2/3 gene (EC50: 1.25 μM).

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QO-40 Chemical Structure

QO-40 Chemical Structure

CAS No. : 1259536-70-3

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Based on 1 publication(s) in Google Scholar

QO-40 Related Antibodies

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Description

QO-40 is a pyrazolo[1,5-a]pyrimidine-7(4H)-one (PPO) derivative and an activator of the voltage-gated M-type potassium channel KCNQ encoded by the KCNQ2/3 gene (EC50: 1.25 μM)[1][2].

IC50 & Target

vEC50: 1.25 μM (oltage-gated M-type potassium channel)[1]
Cellular Effect
Cell Line Type Value Description References
CHO EC50
1.25 μM
Compound: 15
Activation of KCNQ2/Q3 expressed in CHO cells by atomic absorption Rb'+ efflux assay
Activation of KCNQ2/Q3 expressed in CHO cells by atomic absorption Rb'+ efflux assay
[PMID: 21296466]
In Vitro

QO-40 (100 μM) increases KCNQ2/3 currents in CHO cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

QO-40 Related Antibodies

Cell Viability Assay[1]

Cell Line: CHO cells
Concentration: 100 μM
Incubation Time:
Result: Increased the amplitude of the activated outward current at 0 mV.
Molecular Weight

377.75

Formula

C18H11ClF3N3O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C=C(CCl)NC2=C(C3=C4C=CC=CC4=CC=C3)C(C(F)(F)F)=NN12
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (330.91 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6473 mL 13.2363 mL 26.4725 mL
5 mM 0.5295 mL 2.6473 mL 5.2945 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6473 mL 13.2363 mL 26.4725 mL 66.1813 mL
5 mM 0.5295 mL 2.6473 mL 5.2945 mL 13.2363 mL
10 mM 0.2647 mL 1.3236 mL 2.6473 mL 6.6181 mL
15 mM 0.1765 mL 0.8824 mL 1.7648 mL 4.4121 mL
20 mM 0.1324 mL 0.6618 mL 1.3236 mL 3.3091 mL
25 mM 0.1059 mL 0.5295 mL 1.0589 mL 2.6473 mL
30 mM 0.0882 mL 0.4412 mL 0.8824 mL 2.2060 mL
40 mM 0.0662 mL 0.3309 mL 0.6618 mL 1.6545 mL
50 mM 0.0529 mL 0.2647 mL 0.5295 mL 1.3236 mL
60 mM 0.0441 mL 0.2206 mL 0.4412 mL 1.1030 mL
80 mM 0.0331 mL 0.1655 mL 0.3309 mL 0.8273 mL
100 mM 0.0265 mL 0.1324 mL 0.2647 mL 0.6618 mL
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QO-40 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

QO-401259536-70-3QO40QO 40Potassium ChannelKcsAInhibitorinhibitorinhibit

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