2. Anti-infection Membrane Transporter/Ion Channel
  3. Dengue virus Flavivirus Parasite Potassium Channel
  4. Quinine dihydrochloride

Quinine dihydrochloride is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine dihydrochloride is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM.

For research use only. We do not sell to patients.

Quinine dihydrochloride Chemical Structure

Quinine dihydrochloride Chemical Structure

CAS No. : 60-93-5

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Quinine dihydrochloride Related Antibodies

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Description

Quinine dihydrochloride is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine dihydrochloride is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM[1][2].

IC50 & Target

Plasmodium

 

In Vitro

Quinine dihydrochloride (150 μM, 30 min) inhibits the proliferation and cytostatic effects of DENV (Dengue virus) in human hepatocarcinoma HepG2 cell line[1].
Quinine dihydrochloride (37.5-150 μM, 24 hours) significantly reduces viral DENV RNA and protein levels in a dose-dependent manner in human hepatocarcinoma HepG2 cell line [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Quinine dihydrochloride Related Antibodies

Cell Proliferation Assay[1]

Cell Line: Human hepatocarcinoma cell line(HepG2)
Concentration: 150 μM
Incubation Time: 30 min
Result: Inhibited DENV virus replication with 19% yield compared to untreated. Reduced DENV-positive cells from 23.28% to 12.05% in a dose-dependent manner.
In Vivo

Quinine dihydrochloride (oral gavage, 12 or 15 mg/kg, every week, 16 weeks) has some tumor suppressing effect on skin cancer in Swiss albino mice[2].
Quinine dihydrochloride (oral gavage, 10 mg/kg, everyday, 8 weeks) causes a decrease in the antioxidant defense system of rat testicular tissue such as SOD, CAT and GSH enzyme activity in male adult albino rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss albino mice 7-8-weeks (weighing 24 g)[2]
Dosage: 12 mg/kg, 15 mg/kg
Administration: Oral gavage; every week; 16 weeks
Result: Resulted in a significant reduction in tumor size and weight at 12 mg/kg and little effect at higher dose of 15 mg/kg.
Clinical Trial
Molecular Weight

397.34

Formula

C20H26Cl2N2O2
CAS No.
SMILES

C=C[C@H](C[N@@]1CC2)[C@H]2C[C@@H]1[C@H](O)C3=CC=NC4=CC=C(OC)C=C34.Cl.Cl
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Quinine dihydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quinine60-93-5Dengue virusFlavivirusParasitePotassium ChannelDENVKcsAanti-malarialcinchonaineInhibitorinhibitorinhibit

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