2. Anti-infection Membrane Transporter/Ion Channel
  3. Dengue virus Flavivirus Parasite Potassium Channel
  4. Quinine hydrochloride dihydrate

Quinine hydrochloride dihydrate 

Cat. No.: HY-B0433A Purity: ≥98.0%
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Quinine hydrochloride dihydrate (Qualaquin) is an orally active and can be used in anti-malarial studies. Quinine hydrochloride dihydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM.

For research use only. We do not sell to patients.

Quinine hydrochloride dihydrate Chemical Structure

Quinine hydrochloride dihydrate Chemical Structure

CAS No. : 6119-47-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 28 In-stock
Solution
10 mM * 1 mL in DMSO USD 28 In-stock
Solid
5 g USD 25 In-stock
10 g USD 40 In-stock
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Based on 3 publication(s) in Google Scholar

Other Forms of Quinine hydrochloride dihydrate:

Quinine hydrochloride dihydrate Related Antibodies

Top Publications Citing Use of Products

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Quinine hydrochloride dihydrate (Qualaquin) is an orally active and can be used in anti-malarial studies. Quinine hydrochloride dihydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM[1][2].

IC50 & Target

Plasmodium

 

In Vitro

Quinine hydrochloride dihydrate (150 μM, 30 min) inhibits the proliferation and cytostatic effects of DENV (Dengue virus) in human hepatocarcinoma HepG2 cell line[1].
Quinine hydrochloride dihydrate (37.5-150 μM, 24 hours) significantly reduces viral DENV RNA and protein levels in a dose-dependent manner in human hepatocarcinoma HepG2 cell line[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Quinine hydrochloride dihydrate Related Antibodies

Cell Proliferation Assay[1]

Cell Line: Human hepatocarcinoma cell line(HepG2)
Concentration: 150 μM
Incubation Time: 30 min
Result: Inhibited DENV virus replication with 19% yield compared to untreated. Reduced DENV-positive cells from 23.28% to 12.05% in a dose-dependent manner.
In Vivo

Quinine hydrochloride dihydrate (oral gavage, 12 or 15 mg/kg, every week, 16 weeks) has some tumor suppressing effect on skin cancer in Swiss albino mice[2].
Quinine hydrochloride dihydrate (oral gavage, 10 mg/kg, everyday, 8 weeks) causes a decrease in the antioxidant defense system of rat testicular tissue such as SOD, CAT and GSH enzyme activity in male adult albino rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss albino mice 7-8-weeks (weighing 24 g)[2]
Dosage: Swiss albino mice 7-8-weeks (weighing 24 g)[2]
Administration: Oral gavage; every week; 16 weeks
Result: Resulted in a significant reduction in tumor size and weight at 12 mg/kg and little effect at higher dose of 15 mg/kg.
Clinical Trial
Molecular Weight

396.91

Formula

C20H29ClN2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC1=CC2=C(N=CC=C2[C@H]([C@@]3([H])[N@](C[C@@H]4C=C)CC[C@@]4([H])C3)O)C=C1.Cl.O.O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (251.95 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 20 mg/mL (50.39 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5195 mL 12.5973 mL 25.1946 mL
5 mM 0.5039 mL 2.5195 mL 5.0389 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 2.6 mg/mL (6.55 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.5195 mL 12.5973 mL 25.1946 mL 62.9866 mL
5 mM 0.5039 mL 2.5195 mL 5.0389 mL 12.5973 mL
10 mM 0.2519 mL 1.2597 mL 2.5195 mL 6.2987 mL
15 mM 0.1680 mL 0.8398 mL 1.6796 mL 4.1991 mL
20 mM 0.1260 mL 0.6299 mL 1.2597 mL 3.1493 mL
25 mM 0.1008 mL 0.5039 mL 1.0078 mL 2.5195 mL
30 mM 0.0840 mL 0.4199 mL 0.8398 mL 2.0996 mL
40 mM 0.0630 mL 0.3149 mL 0.6299 mL 1.5747 mL
50 mM 0.0504 mL 0.2519 mL 0.5039 mL 1.2597 mL
DMSO 60 mM 0.0420 mL 0.2100 mL 0.4199 mL 1.0498 mL
80 mM 0.0315 mL 0.1575 mL 0.3149 mL 0.7873 mL
100 mM 0.0252 mL 0.1260 mL 0.2519 mL 0.6299 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Quinine hydrochloride dihydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quinine hydrochloride dihydrate6119-47-7Dengue virusFlavivirusParasitePotassium ChannelDENVKcsAQuinineanti-malarialcinchonaineInhibitorinhibitorinhibit

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