2. Protein Tyrosine Kinase/RTK Apoptosis PROTAC
  3. FLT3 Apoptosis Ligands for Target Protein for PROTAC
  4. Quizartinib dihydrochloride

Quizartinib dihydrochloride  (Synonyms: AC220 dihydrochloride)

Cat. No.: HY-14217 Purity: 99.81%
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Quizartinib dihydrochloride (AC220 dihydrochloride) is the dihydrochloride salt form of Quizartinib (HY-13001). Quizartinib dihydrochloride is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a Kd of 1.6 nM. Quizartinib dihydrochloride inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC50s of 4.2 and 1.1 nM, respectively. Quizartinib dihydrochloride can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib dihydrochloride induces apoptosis.

For research use only. We do not sell to patients.

Quizartinib dihydrochloride Chemical Structure

Quizartinib dihydrochloride Chemical Structure

CAS No. : 1132827-21-4

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Based on 34 publication(s) in Google Scholar

Other Forms of Quizartinib dihydrochloride:

Quizartinib dihydrochloride Related Antibodies

Top Publications Citing Use of Products

31 Publications Citing Use of MCE Quizartinib dihydrochloride

WB

    Quizartinib dihydrochloride purchased from MedChemExpress. Usage Cited in: J Med Chem. 2017 Oct 26;60(20):8407-8424.  [Abstract]

    Doseresponsive immunoblotting of the signaling pathway with the cells extracted from tumor tissues of the experimental animal after the 14 and 7 (AC220) treatments.

    Quizartinib dihydrochloride purchased from MedChemExpress. Usage Cited in: Oncotarget. 2016 Jul 26;7(30):47018-47032.  [Abstract]

    A. The established 32D cells are treated with Quizartinib for 2h, followed by 10 ng/mL FL stimulation for 10 minutes. Wt-FLT3 and mutant FLT3 are immunoprecipitated by each tag as indicated and subjected to Western blot. Phosphorylation levels of FLT3, STAT5, AKT and MAPK are examined. B. 32D cells are treated with Quizartinib at the indicated concentrations in the presence or absence of 10 ng/mL FL for 2 hours. Phosphorylation levels of FLT3, STAT5, AKT and MAPK are detected by Western blot.

    Quizartinib dihydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2014 Feb 10;25(2):226-42.  [Abstract]

    Western blot for indicated proteins on lysates from FLT3-ITD-positive primary murine cells expressing either wild-type (WT) or constitutive active (SYK-TEL) SYK and treated for eight hours with indicated doses of AC220.

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    Description

    Quizartinib dihydrochloride (AC220 dihydrochloride) is the dihydrochloride salt form of Quizartinib (HY-13001). Quizartinib dihydrochloride is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a Kd of 1.6 nM. Quizartinib dihydrochloride inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC50s of 4.2 and 1.1 nM, respectively. Quizartinib dihydrochloride can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib dihydrochloride induces apoptosis[1][2][3].

    Molecular Weight

    633.59

    Formula

    C29H34Cl2N6O4S
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(NC1=CC=C(C2=CN3C(SC4=CC(OCCN5CCOCC5)=CC=C34)=N2)C=C1)NC6=NOC(C(C)(C)C)=C6.[H]Cl.[H]Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 33.33 mg/mL (52.60 mM; ultrasonic and adjust pH to 12 with 1 M NaOH; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.5783 mL 7.8915 mL 15.7831 mL
    5 mM 0.3157 mL 1.5783 mL 3.1566 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.5783 mL 7.8915 mL 15.7831 mL 39.4577 mL
    5 mM 0.3157 mL 1.5783 mL 3.1566 mL 7.8915 mL
    10 mM 0.1578 mL 0.7892 mL 1.5783 mL 3.9458 mL
    15 mM 0.1052 mL 0.5261 mL 1.0522 mL 2.6305 mL
    20 mM 0.0789 mL 0.3946 mL 0.7892 mL 1.9729 mL
    25 mM 0.0631 mL 0.3157 mL 0.6313 mL 1.5783 mL
    30 mM 0.0526 mL 0.2631 mL 0.5261 mL 1.3153 mL
    40 mM 0.0395 mL 0.1973 mL 0.3946 mL 0.9864 mL
    50 mM 0.0316 mL 0.1578 mL 0.3157 mL 0.7892 mL
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    Quizartinib dihydrochloride Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Quizartinib1132827-21-4AC220AC 220AC-220FLT3ApoptosisLigands for Target Protein for PROTACCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Target Protein-binding MoietyoralselectiveAMLacutemyeloidleukemiaFLT3-ITDmutationInhibitorinhibitorinhibit

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