2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. R-84760

R-84760 is a selective κ-opioid receptor agonist. R-84760 has antinociceptive effect.

For research use only. We do not sell to patients.

R-84760 Chemical Structure

R-84760 Chemical Structure

CAS No. : 157824-23-2

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R-84760 Related Antibodies

Top Publications Citing Use of Products

View All Opioid Receptor Isoform Specific Products:

View All Isoforms
μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

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Description

R-84760 is a selective κ-opioid receptor agonist. R-84760 has antinociceptive effect[1][2].

IC50 & Target

κ Opioid Receptor/KOR

 

In Vitro

In an opioid receptor binding assay with a guinea pig brain membrane fraction, R-84760 shows a 5 times higher affinity for the kappa-opioid receptor than CI-977 (HY-105235). The selectivity of R-84760 for the kappa-opioid receptor is higher than that of U-69593 (HY-12363)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

R-84760 Related Antibodies
Molecular Weight

435.84

Formula

C19H25Cl3N2OS
CAS No.
SMILES

O=C([C@H]1CCC2=C1C=C(Cl)C(Cl)=C2)N3[C@H](CN4CCCC4)CSCC3.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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R-84760 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

R-84760157824-23-2R84760R 84760Opioid Receptorantinociceptiveκ-opioidkappa-opioidInhibitorinhibitorinhibit

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Product Name:
R-84760
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HY-19206
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