R-84760

Cat. No.: HY-19206: FAQs
Data Sheet Handling Instructions

Molarity Calculator

R-84760 is a selective κ-opioid receptor agonist. R-84760 has antinociceptive effect.

For research use only. We do not sell to patients.

R-84760 Chemical Structure

CAS No. : 157824-23-2

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Opioid Receptor Isoform Specific Products:

View All Isoforms

μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

Biological Activity
Purity & Documentation
References
Customer Review

Description

R-84760 is a selective κ-opioid receptor agonist. R-84760 has antinociceptive effect^[1]^[2].

IC₅₀ & Target

κ Opioid Receptor/KOR

In Vitro

In an opioid receptor binding assay with a guinea pig brain membrane fraction, R-84760 shows a 5 times higher affinity for the kappa-opioid receptor than CI-977 (HY-105235). The selectivity of R-84760 for the kappa-opioid receptor is higher than that of U-69593 (HY-12363)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

435.84

Formula

C₁₉H₂₅Cl₃N₂OS

CAS No.

157824-23-2

SMILES

O=C([C@H]1CCC2=C1C=C(Cl)C(Cl)=C2)N3[C@H](CN4CCCC4)CSCC3.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Fujibayashi K, et al. Pharmacological properties of R-84760, a novel kappa-opioid receptor agonist.[J].European Journal of Pharmacology, 1994, 261(1-2):133-140.

[2]. Fujibayashi K, et al. Profiles of the antinociceptive effect of R-84760, a selective kappa-opioid receptor agonist, in the formalin test in mice. Jpn J Pharmacol. 1995 May;68(1):57-63. [Content Brief]

R-84760 Related Classifications

Neurological Disease

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

R-84760157824-23-2R84760R 84760Opioid Receptorantinociceptiveκ-opioidkappa-opioidInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks