R-BC154 acetate 

R-BC154 acetate is a selective fluorescent α₉β₁ integrin antagonist. R-BC154 acetate acts as a useful high affinity, activation dependent integrin probe, which can be used to investigate α9β1 and α4β1 integrin binding activity^[1].

R-BC154 acetate has 3 times greater affinities for α₉β₁ (K_i=12.7 nM) relative to α₄β₁ (K_i=38.0 nM) under Ca²⁺/Mg²⁺ conditions in human glioblastoma LN18 cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

R-BC154 acetate (10 mg/kg; i.v.) acts as an in vivo probe for bone marrow haemopoietic stem cells in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1212.37

C₅₇H₆₅N₉O₁₅S₃

CC(O)=O.CC/[N+](CC)=C1C=C2OC3=C(C=CC(N(CC)CC)=C3)C(C4=CC=C(S(NCC5=CN([C@H]6CN(S(=O)(C7=CC=CC=C7)=O)[C@H](C(N[C@H](C(O)=O)CC8=CC=C(OC(N9CCCC9)=O)C=C8)=O)C6)N=N5)(=O)=O)C=C4S(=O)([O-])=O)=C2C=C\1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Design, synthesis and binding properties of a fluorescent α9β1/α4β1 integrin antagonist and its application as an in vivo probe for bone marrow haemopoietic stem cells. Org Biomol Chem. 2014 Feb 14;12(6):965-78.  [Content Brief]