(R)-JNJ-40418677

Cat. No.: HY-100604A Purity: 99.27%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

(R)-JNJ-40418677 is the R-enantiomer of JNJ-40418677 (HY-100604).

For research use only. We do not sell to patients.

(R)-JNJ-40418677 Chemical Structure

Size	Stock	Quantity

Free Sample (0.1 - 0.5 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Other Forms of (R)-JNJ-40418677:

JNJ-40418677 Get quote

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Description

(R)-JNJ-40418677 is the R-enantiomer of JNJ-40418677 (HY-100604)^[1].

Molecular Weight

480.44

Formula

C₂₆H₂₂F₆O₂

CAS No.

1146594-85-5

Appearance

Solid

Color

White to off-white

SMILES

CC(C)C[C@H](C1=CC(C2=CC=C(C=C2)C(F)(F)F)=CC(C3=CC=C(C=C3)C(F)(F)F)=C1)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (208.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0814 mL	10.4071 mL	20.8143 mL
5 mM	0.4163 mL	2.0814 mL	4.1629 mL
10 mM	0.2081 mL	1.0407 mL	2.0814 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.27%

Select Batch:

Data Sheet (270 KB) SDS (251 KB)

COA (249 KB) HNMR (143 KB) RP-HPLC (246 KB) LCMS (386 KB)

Handling Instructions (2659 KB)

References

[1]. Van Broeck B, et al. Chronic treatment with a novel γ-secretase modulator, JNJ-40418677, inhibits amyloid plaque formation in a mouse model of Alzheimer's disease. Br J Pharmacol. 2011 May;163(2):375-89. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0814 mL	10.4071 mL	20.8143 mL	52.0356 mL
	5 mM	0.4163 mL	2.0814 mL	4.1629 mL	10.4071 mL
	10 mM	0.2081 mL	1.0407 mL	2.0814 mL	5.2036 mL
	15 mM	0.1388 mL	0.6938 mL	1.3876 mL	3.4690 mL
	20 mM	0.1041 mL	0.5204 mL	1.0407 mL	2.6018 mL
	25 mM	0.0833 mL	0.4163 mL	0.8326 mL	2.0814 mL
	30 mM	0.0694 mL	0.3469 mL	0.6938 mL	1.7345 mL
	40 mM	0.0520 mL	0.2602 mL	0.5204 mL	1.3009 mL
	50 mM	0.0416 mL	0.2081 mL	0.4163 mL	1.0407 mL
	60 mM	0.0347 mL	0.1735 mL	0.3469 mL	0.8673 mL
	80 mM	0.0260 mL	0.1301 mL	0.2602 mL	0.6504 mL
	100 mM	0.0208 mL	0.1041 mL	0.2081 mL	0.5204 mL

(R)-JNJ-40418677 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-JNJ-404186771146594-85-5γ-secretaseAmyloid-βGamma secretaseβ-amyloid peptideAβAbetaInhibitorinhibitorinhibit

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