2. NF-κB
  3. NF-κB
  4. (R)-(-)-Ibuprofen-d3

(R)-(-)-Ibuprofen-d3  (Synonyms: (R)-Ibuprofen-d3)

Cat. No.: HY-78131BS Purity: 99.97%
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(R)-(-)-Ibuprofen-d3 is the deuterium labeled (R)-(-)-Ibuprofen. (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.

For research use only. We do not sell to patients.

(R)-(-)-Ibuprofen-d<sub>3</sub> Chemical Structure

(R)-(-)-Ibuprofen-d3 Chemical Structure

CAS No. : 121702-86-1

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1 mg USD 370 In-stock
5 mg USD 1120 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of (R)-(-)-Ibuprofen-d3:

(R)-(-)-Ibuprofen-d3 Related Antibodies

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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Description

(R)-(-)-Ibuprofen-d3 is the deuterium labeled (R)-(-)-Ibuprofen. (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(R)-(-)-Ibuprofen-d3 Related Antibodies
Molecular Weight

209.30

Formula

C13H15D3O2
CAS No.
Unlabeled CAS

51146-57-7
Appearance

Solid

Color

White to off-white

SMILES

OC([C@@H](C1=CC=C(C=C1)CC(C)C)C([2H])([2H])[2H])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : ≥ 60 mg/mL (286.67 mM)

Ethanol : ≥ 60 mg/mL (286.67 mM)

DMSO : ≥ 50 mg/mL (238.89 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : ≥ 50 mg/mL (238.89 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : ≥ 45 mg/mL (215.00 mM)

DMF : ≥ 45 mg/mL (215.00 mM)

PBS (pH 7.2) : ≥ 2 mg/mL (9.56 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7778 mL 23.8892 mL 47.7783 mL
5 mM 0.9556 mL 4.7778 mL 9.5557 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
PBS (pH 7.2) / DMF / DMF / DMSO / DMSO / Ethanol / Ethanol 1 mM 4.7778 mL 23.8892 mL 47.7783 mL 119.4458 mL
5 mM 0.9556 mL 4.7778 mL 9.5557 mL 23.8892 mL
DMF / DMF / DMSO / DMSO / Ethanol / Ethanol 10 mM 0.4778 mL 2.3889 mL 4.7778 mL 11.9446 mL
15 mM 0.3185 mL 1.5926 mL 3.1852 mL 7.9631 mL
20 mM 0.2389 mL 1.1945 mL 2.3889 mL 5.9723 mL
25 mM 0.1911 mL 0.9556 mL 1.9111 mL 4.7778 mL
30 mM 0.1593 mL 0.7963 mL 1.5926 mL 3.9815 mL
40 mM 0.1194 mL 0.5972 mL 1.1945 mL 2.9861 mL
50 mM 0.0956 mL 0.4778 mL 0.9556 mL 2.3889 mL
60 mM 0.0796 mL 0.3982 mL 0.7963 mL 1.9908 mL
80 mM 0.0597 mL 0.2986 mL 0.5972 mL 1.4931 mL
100 mM 0.0478 mL 0.2389 mL 0.4778 mL 1.1945 mL
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(R)-(-)-Ibuprofen-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-(-)-Ibuprofen-d3121702-86-1(R)-Ibuprofen-d3NF-κBNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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