2. Metabolic Enzyme/Protease
  3. Angiotensin-converting Enzyme (ACE)
  4. (R)-MLN-4760

(R)-MLN-4760, the R-enantiomer of MLN-4760, is an ACE2 inhibitor, with an IC50 of 8.4 μM. (R)-MLN-4760 is the less active isomer.

For research use only. We do not sell to patients.

(R)-MLN-4760 Chemical Structure

(R)-MLN-4760 Chemical Structure

CAS No. : 305335-29-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 528 In-stock
Solution
10 mM * 1 mL in DMSO USD 528 In-stock
Solid
5 mg USD 480 In-stock
10 mg USD 720 In-stock
25 mg USD 1350 In-stock
50 mg USD 1960 In-stock
100 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

Other Forms of (R)-MLN-4760:

(R)-MLN-4760 Related Antibodies

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Description

(R)-MLN-4760, the R-enantiomer of MLN-4760, is an ACE2 inhibitor, with an IC50 of 8.4 μM. (R)-MLN-4760 is the less active isomer[1].

IC50 & Target

IC50: 8.4 nM (ACE2)[1]
In Vitro

(R)-MLN-4760 (compound 16RS) is the less active isomer of MLN-4760[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(R)-MLN-4760 Related Antibodies
Molecular Weight

428.31

Formula

C19H23Cl2N3O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@H](CC1=CN=CN1CC2=CC(Cl)=CC(Cl)=C2)N[C@@H](C(O)=O)CC(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 14.29 mg/mL (33.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3348 mL 11.6738 mL 23.3476 mL
5 mM 0.4670 mL 2.3348 mL 4.6695 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3348 mL 11.6738 mL 23.3476 mL 58.3689 mL
5 mM 0.4670 mL 2.3348 mL 4.6695 mL 11.6738 mL
10 mM 0.2335 mL 1.1674 mL 2.3348 mL 5.8369 mL
15 mM 0.1557 mL 0.7783 mL 1.5565 mL 3.8913 mL
20 mM 0.1167 mL 0.5837 mL 1.1674 mL 2.9184 mL
25 mM 0.0934 mL 0.4670 mL 0.9339 mL 2.3348 mL
30 mM 0.0778 mL 0.3891 mL 0.7783 mL 1.9456 mL
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(R)-MLN-4760 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-MLN-4760305335-29-9Angiotensin-converting Enzyme (ACE)ACE2ACECPDAInhibitorinhibitorinhibit

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