2. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel
  3. Dopamine Receptor Potassium Channel
  4. (R)-SKF 38393 hydrochloride

(R)-SKF 38393 hydrochloride  (Synonyms: (±)-SKF-38393 hydrochloride; SKF-38393A hydrochloride)

Cat. No.: HY-12520B
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(R)-SKF 38393 ((±)-SKF-38393) hydrochloride is a potent and selective D1 dopamine receptor antagonist. (R)-SKF 38393 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channel.

For research use only. We do not sell to patients.

(R)-SKF 38393 hydrochloride Chemical Structure

(R)-SKF 38393 hydrochloride Chemical Structure

CAS No. : 81702-42-3

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Based on 1 publication(s) in Google Scholar

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(R)-SKF 38393 hydrochloride Related Antibodies

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Description

(R)-SKF 38393 ((±)-SKF-38393) hydrochloride is a potent and selective D1 dopamine receptor antagonist. (R)-SKF 38393 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channel[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
56 nM
Compound: 2, SKF-38393
Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins
Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins
[PMID: 21862338]
In Vitro

(R)-SKF 38393 hydrochloride ((±)-SKF-38393; 0-100 µM) blocks endogenous GIRK currents induced by either somatostatin or D3 dopamine receptors in AtT-20 cells with IC50 value of 268 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(R)-SKF 38393 hydrochloride Related Antibodies
Molecular Weight

291.77

Formula

C16H18ClNO2
CAS No.
SMILES

OC1=C(C=C2[C@H](CNCCC2=C1)C3=CC=CC=C3)O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(R)-SKF 38393 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-SKF 3839381702-42-3(±)-SKF-38393SKF-38393ADopamine ReceptorPotassium ChannelKcsApotassium channelAtT-20 cellsGIRKInhibitorinhibitorinhibit

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