2. Membrane Transporter/Ion Channel
  3. CFTR
  4. (R)-Vanzacaftor

(R)-Vanzacaftor  (Synonyms: (R)-VX-121)

Cat. No.: HY-145603A Purity: 98.07% ee.: 100.00%
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(R)-Vanzacaftor ((R)-VX-121) is a regulator of cystic fibrosis transmembrane conduction regulator (CFTR).

For research use only. We do not sell to patients.

(R)-Vanzacaftor Chemical Structure

(R)-Vanzacaftor Chemical Structure

CAS No. : 2374124-48-6

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1 mg USD 1600 In-stock
5 mg USD 4000 In-stock
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Based on 1 publication(s) in Google Scholar

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(R)-Vanzacaftor Related Antibodies

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Description

(R)-Vanzacaftor ((R)-VX-121) is a regulator of cystic fibrosis transmembrane conduction regulator (CFTR)[1].

Molecular Weight

617.76

Formula

C32H39N7O4S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC(C)(C[C@](CCC/N=C1NC(S(=O)(N2)=O)=CC=C\1)([H])C3)N3C4=NC(N(C=C5)N=C5OCCC6C7(CC7)C68CC8)=CC=C4C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (161.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6188 mL 8.0938 mL 16.1875 mL
5 mM 0.3238 mL 1.6188 mL 3.2375 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6188 mL 8.0938 mL 16.1875 mL 40.4688 mL
5 mM 0.3238 mL 1.6188 mL 3.2375 mL 8.0938 mL
10 mM 0.1619 mL 0.8094 mL 1.6188 mL 4.0469 mL
15 mM 0.1079 mL 0.5396 mL 1.0792 mL 2.6979 mL
20 mM 0.0809 mL 0.4047 mL 0.8094 mL 2.0234 mL
25 mM 0.0648 mL 0.3238 mL 0.6475 mL 1.6188 mL
30 mM 0.0540 mL 0.2698 mL 0.5396 mL 1.3490 mL
40 mM 0.0405 mL 0.2023 mL 0.4047 mL 1.0117 mL
50 mM 0.0324 mL 0.1619 mL 0.3238 mL 0.8094 mL
60 mM 0.0270 mL 0.1349 mL 0.2698 mL 0.6745 mL
80 mM 0.0202 mL 0.1012 mL 0.2023 mL 0.5059 mL
100 mM 0.0162 mL 0.0809 mL 0.1619 mL 0.4047 mL
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(R)-Vanzacaftor Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-Vanzacaftor2374124-48-6(R)-VX-121CFTRCystic fibrosis transmembrane conductance regulatorRegulatorCystic fibrosisInhibitorinhibitorinhibit

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