2. GPCR/G Protein Immunology/Inflammation
  3. CCR
  4. (Rac)-PF-4136309

(Rac)-PF-4136309 is an isoform of PF-4136309 (HY-13245), which is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2.

For research use only. We do not sell to patients.

(Rac)-PF-4136309 Chemical Structure

(Rac)-PF-4136309 Chemical Structure

CAS No. : 857679-55-1

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Other Forms of (Rac)-PF-4136309:

(Rac)-PF-4136309 Related Antibodies

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CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

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Description

(Rac)-PF-4136309 is an isoform of PF-4136309 (HY-13245), which is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2.

Molecular Weight

568.59

Formula

C29H31F3N6O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NCC(N1C[C@@H](NC2CCC(C3=NC=C(C4=NC=CC=N4)C=C3)(O)CC2)CC1)=O)C5=CC=CC(C(F)(F)F)=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥98.0%

COA (251 KB)

Handling Instructions (2659 KB)
References
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(Rac)-PF-4136309 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-PF-4136309857679-55-1(Rac)-INCB8761CCRCC chemokine receptorInhibitorinhibitorinhibit

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(Rac)-PF-4136309
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