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  4. (s)-PF-4136309

(s)-PF-4136309  (Synonyms: (s)-INCB8761)

Cat. No.: HY-13245A Purity: 98.93%
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(s)-PF-4136309 is the isomer of PF-4136309 (HY-13245), and can be used as an experimental control. PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2.

For research use only. We do not sell to patients.

(s)-PF-4136309 Chemical Structure

(s)-PF-4136309 Chemical Structure

CAS No. : 1372407-07-2

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5 mg USD 650 In-stock
10 mg USD 980 In-stock
50 mg USD 2200 In-stock
100 mg USD 3000 In-stock
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Based on 1 publication(s) in Google Scholar

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(s)-PF-4136309 Related Antibodies

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Description

(s)-PF-4136309 is the isomer of PF-4136309 (HY-13245), and can be used as an experimental control. PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2.

Molecular Weight

568.59

Formula

C29H31F3N6O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@]1(CC[C@@](CC1)([H])N[C@@H]2CN(CC2)C(CNC(C3=CC=CC(C(F)(F)F)=C3)=O)=O)C4=NC=C(C=C4)C5=NC=CC=N5
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (87.94 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7587 mL 8.7937 mL 17.5874 mL
5 mM 0.3517 mL 1.7587 mL 3.5175 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7587 mL 8.7937 mL 17.5874 mL 43.9684 mL
5 mM 0.3517 mL 1.7587 mL 3.5175 mL 8.7937 mL
10 mM 0.1759 mL 0.8794 mL 1.7587 mL 4.3968 mL
15 mM 0.1172 mL 0.5862 mL 1.1725 mL 2.9312 mL
20 mM 0.0879 mL 0.4397 mL 0.8794 mL 2.1984 mL
25 mM 0.0703 mL 0.3517 mL 0.7035 mL 1.7587 mL
30 mM 0.0586 mL 0.2931 mL 0.5862 mL 1.4656 mL
40 mM 0.0440 mL 0.2198 mL 0.4397 mL 1.0992 mL
50 mM 0.0352 mL 0.1759 mL 0.3517 mL 0.8794 mL
60 mM 0.0293 mL 0.1466 mL 0.2931 mL 0.7328 mL
80 mM 0.0220 mL 0.1099 mL 0.2198 mL 0.5496 mL
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(s)-PF-4136309 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(s)-PF-41363091372407-07-2(s)-INCB8761OthersInhibitorinhibitorinhibit

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