2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. (Rac)-VU 6008667

(Rac)-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) (IC50=1.8 μM, pIC50= 5.75), has high CNS penetration.

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(Rac)-VU 6008667 Chemical Structure

(Rac)-VU 6008667 Chemical Structure

CAS No. : 2092917-63-8

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Other Forms of (Rac)-VU 6008667:

(Rac)-VU 6008667 Related Antibodies

Top Publications Citing Use of Products

View All mAChR Isoform Specific Products:

View All Isoforms
mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

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Description

(Rac)-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) (IC50=1.8 μM, pIC50= 5.75), has high CNS penetration[1].

IC50 & Target

mAChR5

 

Molecular Weight

438.85

Formula

C24H17ClF2N2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N2C(N(C(C3=CC=C(F)C(F)=C3)=O)CC2)(C4=CC=C(Cl)C(C)=C4)C5=C1C=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (284.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2787 mL 11.3934 mL 22.7868 mL
5 mM 0.4557 mL 2.2787 mL 4.5574 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2787 mL 11.3934 mL 22.7868 mL 56.9671 mL
5 mM 0.4557 mL 2.2787 mL 4.5574 mL 11.3934 mL
10 mM 0.2279 mL 1.1393 mL 2.2787 mL 5.6967 mL
15 mM 0.1519 mL 0.7596 mL 1.5191 mL 3.7978 mL
20 mM 0.1139 mL 0.5697 mL 1.1393 mL 2.8484 mL
25 mM 0.0911 mL 0.4557 mL 0.9115 mL 2.2787 mL
30 mM 0.0760 mL 0.3798 mL 0.7596 mL 1.8989 mL
40 mM 0.0570 mL 0.2848 mL 0.5697 mL 1.4242 mL
50 mM 0.0456 mL 0.2279 mL 0.4557 mL 1.1393 mL
60 mM 0.0380 mL 0.1899 mL 0.3798 mL 0.9495 mL
80 mM 0.0285 mL 0.1424 mL 0.2848 mL 0.7121 mL
100 mM 0.0228 mL 0.1139 mL 0.2279 mL 0.5697 mL
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(Rac)-VU 6008667 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-VU 60086672092917-63-8mAChRMuscarinic acetylcholine receptorCNS,penetrationInhibitorinhibitorinhibit

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