(Rac)-VU 6008667

Cat. No.: HY-101281A: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

(Rac)-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) (IC₅₀=1.8 μM, pIC₅₀= 5.75), has high CNS penetration.

For research use only. We do not sell to patients.

(Rac)-VU 6008667 Chemical Structure

CAS No. : 2092917-63-8

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

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This product is a controlled substance and not for sale in your territory.

Other Forms of (Rac)-VU 6008667:

VU 6008667 Get quote
(R)-VU 6008667 Get quote

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•Related Small Molecules:

•Related Proteins:

View All mAChR Isoform Specific Products:

View All Isoforms

mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

Biological Activity
Purity & Documentation
References
Customer Review

Description

(Rac)-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) (IC₅₀=1.8 μM, pIC₅₀= 5.75), has high CNS penetration^[1].

IC₅₀ & Target

mAChR5

Molecular Weight

438.85

Formula

C₂₄H₁₇ClF₂N₂O₂

CAS No.

2092917-63-8

Appearance

Solid

Color

White to off-white

SMILES

O=C1N2C(N(C(C3=CC=C(F)C(F)=C3)=O)CC2)(C4=CC=C(Cl)C(C)=C4)C5=C1C=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (284.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2787 mL	11.3934 mL	22.7868 mL
5 mM	0.4557 mL	2.2787 mL	4.5574 mL
10 mM	0.2279 mL	1.1393 mL	2.2787 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.85%

Select Batch:

Data Sheet (279 KB) SDS (252 KB)

COA (260 KB) HNMR (204 KB) LCMS (120 KB)

Handling Instructions (2659 KB)

References

[1]. McGowan KM et al, Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1356-1359. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2787 mL	11.3934 mL	22.7868 mL	56.9671 mL
	5 mM	0.4557 mL	2.2787 mL	4.5574 mL	11.3934 mL
	10 mM	0.2279 mL	1.1393 mL	2.2787 mL	5.6967 mL
	15 mM	0.1519 mL	0.7596 mL	1.5191 mL	3.7978 mL
	20 mM	0.1139 mL	0.5697 mL	1.1393 mL	2.8484 mL
	25 mM	0.0911 mL	0.4557 mL	0.9115 mL	2.2787 mL
	30 mM	0.0760 mL	0.3798 mL	0.7596 mL	1.8989 mL
	40 mM	0.0570 mL	0.2848 mL	0.5697 mL	1.4242 mL
	50 mM	0.0456 mL	0.2279 mL	0.4557 mL	1.1393 mL
	60 mM	0.0380 mL	0.1899 mL	0.3798 mL	0.9495 mL
	80 mM	0.0285 mL	0.1424 mL	0.2848 mL	0.7121 mL
	100 mM	0.0228 mL	0.1139 mL	0.2279 mL	0.5697 mL

(Rac)-VU 6008667 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-VU 60086672092917-63-8mAChRMuscarinic acetylcholine receptorCNS,penetrationInhibitorinhibitorinhibit

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