2. Cell Cycle/DNA Damage
  3. Deubiquitinase
  4. (Rac)-XL177A

(Rac)-XL177A is the racemic isomer of XL177A (HY-138794). XL177A is a highly potent and selective irreversible USP7 inhibitor with an IC50 of 0.34 nM. XL177A elicits cancer cell-killing effects through a p53-dependent mechanism.

For research use only. We do not sell to patients.

(Rac)-XL177A Chemical Structure

(Rac)-XL177A Chemical Structure

CAS No. : 2417089-73-5

Size Price Stock Quantity
5 mg USD 235 In-stock
10 mg USD 375 In-stock
25 mg USD 750 In-stock
50 mg USD 1200 In-stock
100 mg USD 1920 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of (Rac)-XL177A:

(Rac)-XL177A Related Antibodies

Top Publications Citing Use of Products

View All Deubiquitinase Isoform Specific Products:

View All Isoforms
USP1 USP2 USP7 USP8 USP30 UCHL1

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

(Rac)-XL177A is the racemic isomer of XL177A (HY-138794). XL177A is a highly potent and selective irreversible USP7 inhibitor with an IC50 of 0.34 nM. XL177A elicits cancer cell-killing effects through a p53-dependent mechanism[1].

Molecular Weight

861.47

Formula

C48H57ClN8O5
CAS No.
Appearance

Solid

SMILES

O=C(C(C=CC1=C2Cl)=CC1=NC3=C2CCCC3)NCCCC(CC4=CC=CC=C4)C(N5CCC(CN6C=NC7=C(C=CC(NC(CCN8CCN(C)CC8)=O)=C7)C6=O)(O)CC5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 70 mg/mL (81.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1608 mL 5.8040 mL 11.6081 mL
5 mM 0.2322 mL 1.1608 mL 2.3216 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1608 mL 5.8040 mL 11.6081 mL 29.0202 mL
5 mM 0.2322 mL 1.1608 mL 2.3216 mL 5.8040 mL
10 mM 0.1161 mL 0.5804 mL 1.1608 mL 2.9020 mL
15 mM 0.0774 mL 0.3869 mL 0.7739 mL 1.9347 mL
20 mM 0.0580 mL 0.2902 mL 0.5804 mL 1.4510 mL
25 mM 0.0464 mL 0.2322 mL 0.4643 mL 1.1608 mL
30 mM 0.0387 mL 0.1935 mL 0.3869 mL 0.9673 mL
40 mM 0.0290 mL 0.1451 mL 0.2902 mL 0.7255 mL
50 mM 0.0232 mL 0.1161 mL 0.2322 mL 0.5804 mL
60 mM 0.0193 mL 0.0967 mL 0.1935 mL 0.4837 mL
80 mM 0.0145 mL 0.0726 mL 0.1451 mL 0.3628 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

(Rac)-XL177A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-XL177A2417089-73-5DeubiquitinaseDUBsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
(Rac)-XL177A
Cat. No.:
HY-138794A
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.