(±)-cis-Sertraline-d₃ hydrochloride

Name: (±)-cis-Sertraline-d 3 hydrochloride
Brand: MedChemExpress
SKU: HY-B0176AS1
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0176AS1 Purity: 99.54%: FAQs
Data Sheet SDS COA Handling Instructions

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(±)-cis-Sertraline-d₃ (hydrochloride) is the deuterium labeled Sertraline hydrochloride. Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline hydrochloride is researched for a number of diseases, such as major depressive disorder and obsessive[1][2].

For research use only. We do not sell to patients.

(±)-cis-Sertraline-d<sub>3</sub> hydrochloride Chemical Structure

(±)-cis-Sertraline-d₃ hydrochloride Chemical Structure

CAS No. : 1217741-83-7

Size	Price	Stock	Quantity
1 mg	USD 465	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1165	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (±)-cis-Sertraline-d₃ hydrochloride:

Sertraline hydrochloride In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

345.71

Formula

C₁₇H₁₅D₃Cl₃N

CAS No.

1217741-83-7

Unlabeled CAS

79559-97-0

Appearance

Solid

Color

White to off-white

SMILES

[2H]C([2H])([2H])N[C@@H]1C2=CC=CC=C2[C@H](C3=CC(Cl)=C(C=C3)Cl)CC1.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (144.63 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8926 mL	14.4630 mL	28.9260 mL
5 mM	0.5785 mL	2.8926 mL	5.7852 mL
10 mM	0.2893 mL	1.4463 mL	2.8926 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.54%

Select Batch:

Data Sheet (274 KB) SDS (701 KB)

COA (251 KB) Elemental Analysis Report (109 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Murdoch D, et al. Sertraline. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depression and obsessive-compulsive disorder. Drugs. 1992 Oct;44(4):604-24. [Content Brief]

[3]. Koe BK. Preclinical pharmacology of sertraline: a potent and specific inhibitor of serotonin reuptake. J Clin Psychiatry. 1990 Dec;51 Suppl B:13-7. [Content Brief]

[4]. Xiang X, et, al. Anti-depressive Effect of Arctiin by Attenuating Neuroinflammation via HMGB1/TLR4- And TNF-α/TNFR1-mediated NF-κB Activation. ACS Chem Neurosci. 2020 Jul 1. [Content Brief]

[5]. Lei M, et, al. Sex Differences in Antidepressant Effect of Sertraline in Transgenic Mouse Models. Front Cell Neurosci. 2019 Feb 1; 13:24. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8926 mL	14.4630 mL	28.9260 mL	72.3149 mL
	5 mM	0.5785 mL	2.8926 mL	5.7852 mL	14.4630 mL
	10 mM	0.2893 mL	1.4463 mL	2.8926 mL	7.2315 mL
	15 mM	0.1928 mL	0.9642 mL	1.9284 mL	4.8210 mL
	20 mM	0.1446 mL	0.7231 mL	1.4463 mL	3.6157 mL
	25 mM	0.1157 mL	0.5785 mL	1.1570 mL	2.8926 mL
	30 mM	0.0964 mL	0.4821 mL	0.9642 mL	2.4105 mL
	40 mM	0.0723 mL	0.3616 mL	0.7231 mL	1.8079 mL
	50 mM	0.0579 mL	0.2893 mL	0.5785 mL	1.4463 mL
	60 mM	0.0482 mL	0.2410 mL	0.4821 mL	1.2052 mL
	80 mM	0.0362 mL	0.1808 mL	0.3616 mL	0.9039 mL
	100 mM	0.0289 mL	0.1446 mL	0.2893 mL	0.7231 mL