2. Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  3. Drug Metabolite Monoamine Transporter
  4. Radafaxine

Radafaxine  (Synonyms: (S,S)-Hydroxybupropion; GW-353162A free base; BW-306U free base)

Cat. No.: HY-137107
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Radafaxine ((S,S)-Hydroxybupropion) is an antidepressant. Radafaxine blocks dopamine transporters (DAT). Radafaxine is an active metabolite of Bupropion.

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Radafaxine Chemical Structure

Radafaxine Chemical Structure

CAS No. : 192374-14-4

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Radafaxine Related Antibodies

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Description

Radafaxine ((S,S)-Hydroxybupropion) is an antidepressant. Radafaxine blocks dopamine transporters (DAT). Radafaxine is an active metabolite of Bupropion[1][2].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
> 100 μM
Compound: (2S,3S)-4a
Inhibition of [3H]dopamine reuptake at human DAT expressed in HEK293 cells after 90 mins by scintillation counting
Inhibition of [3H]dopamine reuptake at human DAT expressed in HEK293 cells after 90 mins by scintillation counting
[PMID: 20509659]
HEK293 IC50
> 100 μM
Compound: (2S,3S)-4a
Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells after 90 mins by scintillation counting
Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells after 90 mins by scintillation counting
[PMID: 20509659]
HEK293 IC50
9900 nM
Compound: (2S,3S)-4a
Inhibition of [3H]norepinephrine reuptake at human NET expressed in HEK293 cells after 90 mins by scintillation counting
Inhibition of [3H]norepinephrine reuptake at human NET expressed in HEK293 cells after 90 mins by scintillation counting
[PMID: 20509659]
SH-SY5Y IC50
6.5 μM
Compound: (2S,3S)-4a
Antagonist activity at alpha3beta4 nicotinic receptor in human SH-SY5Y cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx at by liquid scintillation counting
Antagonist activity at alpha3beta4 nicotinic receptor in human SH-SY5Y cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx at by liquid scintillation counting
[PMID: 20509659]
TE-671 IC50
7.6 μM
Compound: (2S,3S)-4a
Antagonist activity at alpha-1-beta-1-gamma-delta nicotinic receptor in human TE671 cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx at by liquid scintillation counting
Antagonist activity at alpha-1-beta-1-gamma-delta nicotinic receptor in human TE671 cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx at by liquid scintillation counting
[PMID: 20509659]
Molecular Weight

255.74

Formula

C13H18ClNO2
CAS No.
SMILES

O[C@]1(C2=CC=CC(Cl)=C2)[C@H](C)NC(C)(C)CO1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Radafaxine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Radafaxine192374-14-4(S,S)-HydroxybupropionGW-353162ABW-306UDrug MetaboliteMonoamine TransporterantidepressantDATBupropionInhibitorinhibitorinhibit

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