2. Anti-infection
  3. Bacterial Antibiotic
  4. Ramoplanin

Ramoplanin is a broad-spectrum lipoglycodepsipeptide antibiotic derived from the Actinoplanes spp with with activity against gram-positive bacteria.

For research use only. We do not sell to patients.

Ramoplanin Chemical Structure

Ramoplanin Chemical Structure

CAS No. : 76168-82-6

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Based on 1 publication(s) in Google Scholar

Ramoplanin Related Antibodies

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Description

Ramoplanin is a broad-spectrum lipoglycodepsipeptide antibiotic derived from the Actinoplanes spp with with activity against gram-positive bacteria[1][2].

IC50 & Target

Glycopeptide

 

In Vitro

Ramoplanin exerts its bactericidal activity against gram-positive aerobic and anaerobic bacteria by blocking peptidoglycan synthesis via lipid II[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ramoplanin Related Antibodies
In Vivo

Ramoplanin (100, 500 μg/ml; p.o.; for 8 days) suppresses vancomycin-resistant Enterococcus (VRE) to undetectable level during treatment[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CF1 mice (25-30 g)[1]
Dosage: 100 μg/ml, 500 μg/ml
Administration: Oral administration; for 8 days
Result: Developed undetectable levels of VRE in stool during treatment.
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Ramoplanin]
Structure Classification
Initial Source

Actinoplanes spp
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 33.33 mg/mL (Need ultrasonic)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.50%

COA (243 KB) RP-HPLC (205 KB)

Handling Instructions (2659 KB)
References
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Ramoplanin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ramoplanin76168-82-6BacterialAntibioticlipoglycodepsipeptideantibioticvancomycin-resistantEnterococcusInhibitorinhibitorinhibit

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