Ranitidine-d₆ hydrochloride

Name: Ranitidine-d 6 hydrochloride
Brand: MedChemExpress
SKU: HY-B0281AS
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0281AS Purity: 97.00%: FAQs
Data Sheet SDS COA Handling Instructions

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Ranitidine-d₆ (hydrochloride) is the deuterium labeled Ranitidine hydrochloride. Ranitidine hydrochloride is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion. Ranitidine hydrochloride is a weak inhibitor of CYP2C19 and CYP2C9[1][2].

For research use only. We do not sell to patients.

Ranitidine-d<sub>6</sub> hydrochloride Chemical Structure

Ranitidine-d₆ hydrochloride Chemical Structure

CAS No. : 1185238-09-8

Size	Price	Stock	Quantity
1 mg	USD 370	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Ranitidine-d₆ hydrochloride:

Ranitidine hydrochloride In-stock

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•Related Small Molecules:

•Related Proteins:

View All Histamine Receptor Isoform Specific Products:

View All Isoforms

H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Histamine Receptor

View All Cytochrome P450 Isoform Specific Products:

View All Isoforms

CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

356.90

Formula

C₁₃H₁₇D₆ClN₄O₃S

CAS No.

1185238-09-8

Unlabeled CAS

66357-59-3

Appearance

Solid

Color

Yellow to brown

SMILES

[2H]C([2H])([2H])N(C([2H])([2H])[2H])CC1=CC=C(CSCCN/C(NC)=C/[N+]([O-])=O)O1.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (140.10 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8019 mL	14.0095 mL	28.0191 mL
5 mM	0.5604 mL	2.8019 mL	5.6038 mL
10 mM	0.2802 mL	1.4010 mL	2.8019 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 97.00%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (247 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Herling, A.W., et al., Inhibition of 14C-aminopyrine accumulation in isolated rabbit gastric glands by the H2-receptor antagonist HOE 760 (TZU-0460). Agents Actions, 1987. 20(1-2): p. 35-9. [Content Brief]

[3]. Leucuta, A., et al., A pharmacokinetic interaction study between omeprazole and the H2-receptor antagonist ranitidine. Drug Metabol Drug Interact, 2004. 20(4): p. 273-81. [Content Brief]

[4]. Antonio Francesco Ciccaglione, et al. Pylera® plus ranitidine vs Pylera® plus esomeprazole in first-line treatment of Helicobacter pylori infection: Two pilot studies. Helicobacter. 2019 Oct;24(5):e12606. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.8019 mL	14.0095 mL	28.0191 mL	70.0476 mL
	5 mM	0.5604 mL	2.8019 mL	5.6038 mL	14.0095 mL
	10 mM	0.2802 mL	1.4010 mL	2.8019 mL	7.0048 mL
	15 mM	0.1868 mL	0.9340 mL	1.8679 mL	4.6698 mL
	20 mM	0.1401 mL	0.7005 mL	1.4010 mL	3.5024 mL
	25 mM	0.1121 mL	0.5604 mL	1.1208 mL	2.8019 mL
	30 mM	0.0934 mL	0.4670 mL	0.9340 mL	2.3349 mL
	40 mM	0.0700 mL	0.3502 mL	0.7005 mL	1.7512 mL
	50 mM	0.0560 mL	0.2802 mL	0.5604 mL	1.4010 mL
	60 mM	0.0467 mL	0.2335 mL	0.4670 mL	1.1675 mL
	80 mM	0.0350 mL	0.1751 mL	0.3502 mL	0.8756 mL
	100 mM	0.0280 mL	0.1401 mL	0.2802 mL	0.7005 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.